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题目:: Effects of glucocorticoids on glioma cells in culture. Minireview on cancer research.
作者:: Freshney(R I)
状态:: 发布时间1984-11-13 , 更新时间 2013-11-21
期刊:: Exp Cell Biol
摘要:: In vitro studies have shown that glucocorticoids have a cytostatic effect on glioma cells at high cell densities but enhance cell survival and proliferation at low cell densities. The cytostatic effect is not cytotoxic and may be mediated via a membrane modification altering cell-cell interaction. Cell interaction is also implicated in differentiation in glial cells and the inducing effect of glucocorticoids may be mediated in part by their effect on cell interaction. Induction of differentiation by glucocorticoids is accompanied by a reduction in malignancy-associated properties and the possibility has emerged that glucocorticoids may be an essential component in attempts to modify the malignant behaviour of glioma cells.
语言:: eng
DOI:

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