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PMID: 6540172 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The three-dimensional structure of retinol-binding protein.

The EMBO journal ·Vol. 3 ·No. 7 ·1984-07-00 ·Pages 1451-4

Newcomer ME, Jones TA, Aqvist J, Sundelin J, Eriksson U, Rask L, Peterson PA

Abstract

The complex of retinol with its carrier protein, retinol-binding protein (RBP) has been crystallized and its three-dimensional structure determined using X-ray crystallography. Its most striking feature is an eight-stranded up-and-down beta barrel core that completely encapsulates the retinol molecule. The retinol molecule lies along the axis of the barrel with the beta-ionone ring innermost and the tip of the isoprene tail close to the surface.

MeSH Terms

Animals Binding Sites Humans Models, Molecular Protein Conformation Rabbits Rats Retinol-Binding Proteins Vitamin A X-Ray Diffraction

Chemicals

Retinol-Binding Proteins Vitamin A

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Newcomer M E

Jones T A

Aqvist J

Sundelin J

Eriksson U

Rask L

Peterson P A

References (15)

15 references, click to expand

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Article Info

Journal

The EMBO journal

Abbr.

EMBO J

ISSN

0261-4189

Published

1984-07-00

Pages

1451-4

Language

English

Region

England

NLM ID

8208664

PMCID

PMC557543

Subset

Grants

NEI NIH HHS · 5ROI EY 02417 · United States

External Links

PubMed source PMC Full Text View journal details

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The three-dimensional structure of retinol-binding protein.

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