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PMID: 6508742 Published · ppublish English Journal Article

Renal transport of monocarboxylic acids. Heterogeneity of lactate-transport systems along the proximal tubule.

The Biochemical journal ·Vol. 223 ·No. 3 ·1984-11-01 ·Pages 803-7

Jørgensen KE, Sheikh MI

Abstract

The characteristics of D- and L-lactate transport in luminal-membrane vesicles derived from whole cortex, from the pars convoluta and from the pars recta of rabbit kidney proximal tubule were studied. It was found that uptake of both isomers in vesicles from whole cortex occurred by means of dual electrogenic transport systems, namely a low-affinity system and a high-affinity system. Uptake of both isomers in vesicles from the pars recta was strictly Na+-dependent and is mediated via a single high-affinity common transport system. Vesicles from the pars convoluta contained a cation-dependent but Na+-unspecific low-affinity common transport system for these compounds. The physiological importance of this system is briefly discussed.

MeSH Terms
Animals Biological Transport In Vitro Techniques Kidney/metabolism Kidney Tubules, Proximal/metabolism Kinetics Lactates/metabolism Lactic Acid Rabbits Sodium/metabolism Stereoisomerism
Chemicals
Lactates Lactic Acid Sodium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jørgensen K E
Sheikh M I
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23 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2230803
Published
1984-11-01
Pages
803-7
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1144365
Subset
IM
External Links
PubMed source DOI: 10.1042/bj2230803 PMC Full Text View journal details
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