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PMID: 6504137 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Microtubule assembly nucleated by isolated centrosomes.

Nature ·Vol. 312 ·No. 5991 ·1984-00-00 ·Pages 232-7

Mitchison T, Kirschner M

Abstract

Microtubules are involved in the morphogenesis of most cells and are the structural basis of the mitotic spindle. We report here that purified centrosomes nucleate the assembly of microtubules with unusual dynamic properties. This may have important implications for the mechanism by which microtubule arrays are organized and stabilized in cells.

MeSH Terms
Animals Cell-Free System Centrioles/ultrastructure Mice Microtubules/physiology,ultrastructure Morphogenesis Polymers Protein Binding Tubulin/physiology
Chemicals
Polymers Tubulin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mitchison T
Kirschner M
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/312232a0
Published
1984-00-00
Pages
232-7
Language
English
Region
England
NLM ID
0410462
Subset
IM
External Links
PubMed source DOI: 10.1038/312232a0 View journal details
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