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PMID: 6492889 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Mutation frequency in human lymphocytes increases with age.

Mechanisms of ageing and development ·Vol. 27 ·No. 1 ·1984-09-00 ·Pages 83-6

Trainor KJ, Wigmore DJ, Chrysostomou A, Dempsey JL, Seshadri R, Morley AA

Abstract

Several theories of ageing predict that somatic mutations should increase with age. This prediction was tested for human lymphocytes using a recently developed clonal technique for enumeration of mutations, and an increase of 1.6% per year in mutations with age was detected.

MeSH Terms

Adolescent Adult Aged Aging Cells, Cultured Child Child, Preschool Clone Cells Humans Infant Infant, Newborn Lymphocytes/cytology Middle Aged Mutation

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Trainor K J

Wigmore D J

Chrysostomou A

Dempsey J L

Seshadri R

Morley A A

Article Info

Journal

Mechanisms of ageing and development

Abbr.

Mech Ageing Dev

ISSN

0047-6374

DOI

10.1016/0047-6374(84)90084-8

Published

1984-09-00

Pages

83-6

Language

English

Region

Ireland

NLM ID

0347227

Subset

External Links

PubMed source DOI: 10.1016/0047-6374(84)90084-8 View journal details

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Mutation frequency in human lymphocytes increases with age.

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