Home LiteratureArticle Details
PMID: 6476814 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Ornithyl amphotericin methyl ester treatment of experimental candidiasis in rats.

Antimicrobial agents and chemotherapy ·Vol. 26 ·No. 1 ·1984-07-00 ·Pages 108-9

Galgiani JN, VanWyck DB

Abstract

After intravenous Candida albicans infection, rats received orinthyl amphotericin methyl ester, amphotericin B, or diluent intravenously. At doses of 0.1 and 0.5 mg/kg, the drugs were equally effective in preventing deaths. However, at doses of 2.0 mg/kg, mortality after treatment with amphotericin B was greater than that after placebo, whereas orinthyl amphotericin methyl ester was fully protective.

MeSH Terms
Amphotericin B/analogs & derivatives,therapeutic use Animals Antifungal Agents/therapeutic use Candidiasis/drug therapy Rats Rats, Inbred Strains
Chemicals
Antifungal Agents methylamphotericin B Amphotericin B
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Galgiani J N
VanWyck D B
References (7)
7 references, click to expand
  1. Turbidimetric studies of growth inhibition of yeasts with three drugs: inquiry into inoculum-dependent susceptibility testing, time of onset of drug effect, and implications for current and newer methods.
    Antimicrob Agents Chemother. 1978 Feb;13(2):249-54 PMID: 646347
  2. Leukoencephalopathy in patients treated with amphotericin B methyl ester.
    J Infect Dis. 1982 Aug;146(2):125-37 PMID: 7108268
  3. Comparative toxicological studies of amphotericin B methyl ester and amphotericin B in mice, rats, and dogs.
    Antimicrob Agents Chemother. 1976 Oct;10(4):687-90 PMID: 984803
  4. Chemotherapy of systemic mycoses (first of two parts).
    N Engl J Med. 1974 Jan 3;290(1):30-2 PMID: 4593887
  5. Increased arabinitol levels in experimental candidiasis in rats: arabinitol appearance rates, arabinitol/creatinine ratios, and severity of infection.
    J Infect Dis. 1982 Sep;146(3):346-52 PMID: 7050256
  6. Polyene macrolide derivatives. I. N-acylation and esterification reactions with amphotericin B.
    J Antibiot (Tokyo). 1972 Apr;25(4):256-8 PMID: 4559649
  7. Polyene macrolide derivatives. II. Physical-chemical properties of polyene macrolide esters and their water soluble salts.
    J Antibiot (Tokyo). 1972 Apr;25(4):259-60 PMID: 4538233
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.26.1.108
Published
1984-07-00
Pages
108-9
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC179929
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.26.1.108 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2