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PMID: 6462325 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Erythrocyte antioxidant enzymes in multiple sclerosis and the effect of hyperbaric oxygen.

Neurochemical research ·Vol. 9 ·No. 4 ·1984-04-00 ·Pages 507-16

Hunter MI, Lao MS, Burtles SS, Davidson DL

Abstract

The activities of catalase, glutathione peroxidase, and glutathione reductase, were not significantly different from normal whereas that of superoxide dismutase was decreased (P less than 0.05) in erythrocytes from patients with multiple sclerosis. Assay of the lipid peroxidation product, malondialdehyde, after incubation of erythrocytes with 10 mM H2O2 under carefully controlled conditions (peroxide stress test) demonstrated that MS erythrocytes are significantly (P less than 0.001) less susceptible to H2O2-induced lipid peroxidation in vitro. This finding suggests that the level of an endogenous antioxidant, possibly vitamin E, may be elevated in MS red cells. After treatment with hyperbaric O2, the activity of MS erythrocyte catalase is significantly (P less than 0.01) elevated by 2-6-fold.

MeSH Terms
Adult Catalase/blood Erythrocytes/enzymology Female Glutathione Peroxidase/blood Glutathione Reductase/blood Humans Hyperbaric Oxygenation Kinetics Male Middle Aged Multiple Sclerosis/enzymology Reference Values Superoxide Dismutase/blood
Chemicals
Catalase Glutathione Peroxidase Superoxide Dismutase Glutathione Reductase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Hunter M I
Lao M S
Burtles S S
Davidson D L
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40 references, click to expand
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Article Info
Journal
Neurochemical research
Abbr.
Neurochem Res
ISSN
0364-3190
DOI
10.1007/BF00964377
Published
1984-04-00
Pages
507-16
Language
English
Region
United States
NLM ID
7613461
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00964377 View journal details
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