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PMID: 6461860 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Regulation of fibrinogen synthesis by plasmin-derived fragments of fibrinogen and fibrin: an indirect feedback pathway.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 5 ·1982-03-00 ·Pages 1530-4

Ritchie DG, Levy BA, Adams MA, Fuller GM

Abstract

The effect of plasmin-derived fibrinogen fragments on the biosynthesis of fibrinogen was investigated in cultured monolayers of rat hepatocytes. Incubating the cells with several concentrations of either fibrinogen or fibrin fragment D or E had no effect on the synthesis and secretion of fibrinogen by these cells. However, if the fragments were incubated with isolated peripheral blood leukocytes, they caused these cells to secrete a factor that when added to the hepatocytes caused an increase in fibrinogen synthesis 4- to 6-fold over controls. Moreover, the hepatocyte-stimulating factor also affected the production of several other proteins produced by the hepatocyte. These results demonstrate that both fragments D and E can stimulate hepatic fibrinogen synthesis via an indirect leukocyte-mediated pathway.

MeSH Terms
Animals Cells, Cultured Feedback Fibrin Fibrinogen Degradation Products/pharmacology Fibrinogen/biosynthesis Fibrinolysin/metabolism Humans Leukocytes/drug effects,physiology Liver/metabolism Rats
Chemicals
Fibrin Fibrinogen Degradation Products Fibrinogen Fibrinolysin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Ritchie D G
Levy B A
Adams M A
Fuller G M
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38 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.5.1530
Published
1982-03-00
Pages
1530-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC346008
Subset
IM
Grants
NHLBI NIH HHS · HL 16445 · United States
External Links
PubMed source DOI: 10.1073/pnas.79.5.1530 PMC Full Text View journal details
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