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题目:: A patient with post-hepatitis B immune deficiency: nonspecific helper factor partially restores the in vitro immune response.
作者:: Sheehy(M J),Miller(N J),Rappeport(J M),Gozes(Y),Parkman(R),Strom(T B),Yunis(E J)
状态:: 发布时间1981-08-20 , 更新时间 2007-11-14
期刊:: Vox Sang
摘要:: A patient with severe post-hepatitis B aplastic anemia had depressed B and T cell responses. In mixed leukocyte culture, her cell were unresponsive to unrelated control stimulating cells, but responded well to a pool of cells from the same unrelated controls. She had reduced production of lymphocyte mitogenic factor (MF), suggesting a helper cell defect, and she had few or no cells reactive with the monoclonal anti-T cell antibodies OKT3, OKT4 or OKT5. Her cells proliferated in response to MF produced by a pool of cells without mitogen, however. Furthermore, her cells became specifically cytotoxic when stimulated by cells plus MF, but not when stimulated by either cells or MF alone. Thus her T cell deficiency was correctable by nonspecific helper factor in vitro.
语言:: eng
DOI:

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