'In situ' immune complex nephritis and basic proteins.

Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association ·Vol. 17 ·1980-00-00 ·Pages 613-20

Vogt A, Schmidt HU, Takamiya H, Batsford S

Abstract

This investigation was designed to clarify the potential role of basic antigens in immune complex nephritis. The GBM is negatively charged and binds cationic substances. We studied 1) whether chemically cationised proteins can bind to the GBM, act as planted antigen, and induce 'in situ' immune complex formation or 2) if a pre-formed cationic antigen antibody complex can localise in the GBM. Results obtained with 5 chemically cationised proteins support the first possibility.

MeSH Terms

Animals Antigen-Antibody Complex/metabolism Basement Membrane/metabolism Cations Ferritins/metabolism Humans Immune Complex Diseases/immunology Immunoglobulin G/metabolism Immunoglobulin M/metabolism Kidney Glomerulus/metabolism Nephritis/immunology Ovalbumin/metabolism Proteins/metabolism Rats Serum Albumin/metabolism

Chemicals

Antigen-Antibody Complex Cations Immunoglobulin G Immunoglobulin M Proteins Serum Albumin Ovalbumin Ferritins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Vogt A

Schmidt H U

Takamiya H

Batsford S

Article Info

Journal

Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association

Abbr.

Proc Eur Dial Transplant Assoc

ISSN

0071-2736

Published

1980-00-00

Pages

613-20

Language

English

Region

England

NLM ID

0355210

Subset

External Links

PubMed source

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'In situ' immune complex nephritis and basic proteins.

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