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PMID: 6446478 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Directionality and nonreciprocality of Chi-stimulated recombination in phage lambda.

Genetics ·Vol. 94 ·No. 2 ·1980-02-00 ·Pages 235-48

Stahl FW, Stahl MM, Malone RE, Crasemann JM

Abstract

Chi's are genetic elements that stimulate generalized recombination in their locale in phage lambda. All Chi's wherever located on lambda's chromosome, act asymmetrically in crosses blocked in DNA replication: (1) They stimulate exchange primarily to their left on the conventional lambda map, and (2) the stimulated exchange is frequently nonreciprocal, the recombinant carrying the Chi element being produced less often than the complementary product.

MeSH Terms
Bacteriophage lambda/genetics Base Sequence Capsid/physiology Centrifugation, Density Gradient DNA, Circular/physiology DNA, Viral/genetics Genes, Viral Models, Genetic Mutation Recombination, Genetic
Chemicals
DNA, Circular DNA, Viral
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Stahl F W
Stahl M M
Malone R E
Crasemann J M
References (9)
9 references, click to expand
  1. Recombination in bacteriophage lambda. I. Mutants deficient in general recombination.
    J Mol Biol. 1968 Jul 14;34(2):261-71 PMID: 5760458
  2. An enhancing role for DNA synthesis in formation of bacteriophage lambda recombinants.
    Proc Natl Acad Sci U S A. 1972 Dec;69(12):3598-601 PMID: 4509320
  3. Rec-mediated recombinational hot spot activity in bacteriophage lambda. I. Hot spot activity associated with spi-deletions and bio substitutions.
    Genetics. 1974 Jul;77(3):409-23 PMID: 4415484
  4. The distribution of crossovers along unreplicated lambda bacteriophage chromosomes.
    Genetics. 1974 Jul;77(3):395-408 PMID: 4416166
  5. Rec-mediated recombinational hot spot activity in bacteriophage lambda. III. Chi mutations are site-mutations stimulating rec-mediated recombination.
    J Mol Biol. 1975 May 15;94(2):203-12 PMID: 1142440
  6. Rec-mediated recombinational hot spot activity in bacteriophage lambda. IV. Effect of heterology on Chi-stimulated crossing over.
    Mol Gen Genet. 1975 Sep 15;140(1):29-37 PMID: 1186661
  7. Maturation of a single lambda phage particle from a dimeric circular lambda DNA.
    Virology. 1976 Oct 15;74(2):414-25 PMID: 790755
  8. A single base-pair change creates a Chi recombinational hotspot in bacteriophage lambda.
    Proc Natl Acad Sci U S A. 1978 Dec;75(12):6182-6 PMID: 282634
  9. Chi.
    Cold Spring Harb Symp Quant Biol. 1979;43 Pt 2:1063-6 PMID: 158459
Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/94.2.235
Published
1980-02-00
Pages
235-48
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1214140
Subset
IM
External Links
PubMed source DOI: 10.1093/genetics/94.2.235 PMC Full Text View journal details
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