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PMID: 6446426 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Current perspectives on the cellular mechanisms of immunologic tolerance.

Clinical and experimental immunology ·Vol. 39 ·No. 2 ·1980-02-00 ·Pages 257-62

Parks DE, Weigle WO

Abstract

暂无摘要

MeSH Terms

Animals Antibody Affinity Antigens/immunology Autoantigens/immunology B-Lymphocytes/immunology Humans Immune Tolerance Lipopolysaccharides/immunology Mice Receptors, Antigen T-Lymphocytes/immunology T-Lymphocytes, Regulatory/immunology

Chemicals

Antigens Autoantigens Lipopolysaccharides Receptors, Antigen

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Parks D E

Weigle W O

References (40)

40 references, click to expand

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Purified protein derivative of tuberculin induces immunoglobulin production in normal mouse spleen cells.
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Termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin).
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Mechanism of thymus-independent immunocyte triggering. Mitogenic activation of B cells results in specific immune responses.
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The tolerant cell: direct evidence for receptor blockade by tolerogen.
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Mitogens as probes for immunocyte activation and cellular cooperation.
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Induction of immunological tolerance to a thymus-dependent antigen in the absence of thymus-derived cells.
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Cell-to-cell interaction in the immune response. X. T-cell-dependent suppression in tolerant mice.
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Restoration of immune competence in tolerant mice by parabiosis to normal mice.
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Hapten-induced B cell paralysis. II. Evidence for trivial mechanisms of tolerance.
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Neonatally induced tolerance to HGG: duration in B cells and absence of specific suppressor cells.
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Induction of immunological tolerance requires that the B cells can respond to the polyclonal B-cell-activating properties of the thymus-independent antigens.
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Induction of tolerance in athymic mice with an antigen which is highly immunogenic in euthymic mice.
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Cellular events in tolerance. VI. Neonatal vs adult B cell tolerance: differences in antigen-binding cell patterns and lipopolysaccharide stimulation.
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Effect of lipopolysaccharide on immunogenicity and tolerogenicity of HGG in C57BL/6J nude mice: evidence for a possible B cell deficiency.
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Polyclonal B-cell activators induce immunological response to autologous serum proteins.
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Cellular basis of persistent tolerance induced by an aggregate free heterologous immunoglobulin.
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Suppressor T-cell memory.
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Irreversible immunological tolerance to thymus-independent antigens is restricted to the clone of B cells having both Ig and PBA receptors for the tolerogen.
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Induction of specific unresponsiveness in normal mouse spleen cells by removing the minority of high avidity antigen-binding cells.
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Induction and mode of action of suppressor cells generated against human gamma globulin. I. An immunologic unresponsive state devoid of demonstrable suppressor cells.
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Immunological tolerance to the thymus-independent antigen dextran can be abrogated by thymus-dependent dextran conjugates: evidence against clonal deletion as the mechanism of tolerance induction.
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Mechanisms of clonal abortion tolerogenesis. I. Response of immature hapten-specific B lymphocytes.
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In vitro effects of Epstein-Barr virus on peripheral blood mononuclear cells from patients with rheumatoid arthritis and normal subjects.
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Immunological unresponsiveness of self-recognizing B lymphocytes to the PBA property of a soluble T cell factor.
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Regulation of B cell unresponsiveness by suppressor cells.
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Multiple pathways of B lymphocyte tolerance.
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Tolerance induction during ontogeny. I. Presence of active suppression in mice rendered tolerant to human gamma-globulin in utero correlates with the breakdown of the tolerant state.
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The induction of hapten-specific immunological tolerance and immunity in B lymphocytes. VI. Differential tolerance susceptibility in adult spleen as a function of B-cell maturation level.
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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1980-02-00

Pages

257-62

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1538073

Subset

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Current perspectives on the cellular mechanisms of immunologic tolerance.

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