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PMID: 6445509 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Sequence analysis of mutations that prevent export of lambda receptor, an Escherichia coli outer membrane protein.

Nature ·Vol. 285 ·No. 5760 ·1980-05-08 ·Pages 82-5

Emr SD, Hedgpeth J, Clément JM, Silhavy TJ, Hofnung M

Abstract

The amino-terminal signal sequence is required for initiation of transmembrane protein transfer of the Escherichia coli lambda receptor protein. Mutations leading to insertion of charged amino acids into or deletion of amino acids from the hydrophobic segment of this sequence prevent export of this outer membrane protein.

MeSH Terms

Amino Acid Sequence Bacterial Proteins/genetics Bacteriophage lambda Base Sequence Cell Membrane/metabolism DNA, Bacterial/genetics Escherichia coli/genetics,ultrastructure Membrane Proteins/genetics,metabolism Mutation Receptors, Virus/genetics

Chemicals

Bacterial Proteins DNA, Bacterial Membrane Proteins Receptors, Virus

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Emr S D

Hedgpeth J

Clément J M

Silhavy T J

Hofnung M

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/285082a0

Published

1980-05-08

Pages

82-5

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

J01639, J01648, K02117

External Links

PubMed source DOI: 10.1038/285082a0 View journal details

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Sequence analysis of mutations that prevent export of lambda receptor, an Escherichia coli outer membrane protein.

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