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PMID: 6444235 Published · ppublish English Journal Article

Participation of suppressor T cells in the immunosuppressive activity of a heteroantiserum to human Ia-like antigens (p23,30).

The Journal of experimental medicine ·Vol. 151 ·No. 1 ·1980-01-01 ·Pages 257-62

Broder S, Mann DL, Waldmann TA

Abstract

We studied the effects of an antiserum to human Ia-like antigens (p23,30) upon the polyclonal activation of normal B cells (cultured with various combination of irradiated and unirradiated T cells) to become immunoglobulin-secreting cells after stimulation with pokeweed mitogen in vitro. We found that the antiserum suppressed immunoglobulin production. The inhibitory effect did not appear to result from a simple interaction at the B-cell/monocyte level alone. Rather, the inhibitory effect required the presence of a radiosensitive subset of autologous suppressor T cells.

MeSH Terms
Animals B-Lymphocytes/immunology Blood Group Antigens Cells, Cultured Humans I Blood-Group System Immune Sera Immunosuppression Therapy Mitogens Rabbits/immunology T-Lymphocytes, Regulatory
Chemicals
Blood Group Antigens I Blood-Group System Immune Sera Mitogens
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Broder S
Mann D L
Waldmann T A
References (24)
24 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.151.1.257
Published
1980-01-01
Pages
257-62
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2185755
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.151.1.257 PMC Full Text View journal details
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