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PMID: 6422919 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Human apolipoprotein A-I--C-III gene complex is located on chromosome 11.

Arteriosclerosis (Dallas, Tex.) ·Vol. 4 ·No. 2 ·1984-00-00 ·Pages 97-102

Bruns GA, Karathanasis SK, Breslow JL

Abstract

The genes for two of the apolipoproteins, apo A-I and apo C-III, previously shown to be within 3kb in the genome, were localized to human chromosome 11 by Southern blot analysis of DNA from human-rodent somatic cell hybrids. These two genes were shown to exhibit polymorphisms associated with dyslipoproteinemia and premature atherosclerosis, and it will now be possible to examine the relationship of these genes to the many others that have been assigned to this chromosome.

MeSH Terms

Animals Apolipoprotein A-I Apolipoprotein C-III Apolipoproteins/genetics Apolipoproteins C Arteriosclerosis/genetics Base Sequence Chromosome Mapping Chromosomes, Human, 6-12 and X Cricetinae Cricetulus DNA/analysis Female Genes Genetic Linkage Humans Hybrid Cells/analysis Male Mice

Chemicals

Apolipoprotein A-I Apolipoprotein C-III Apolipoproteins Apolipoproteins C DNA

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Bruns G A

Karathanasis S K

Breslow J L

Article Info

Journal

Arteriosclerosis (Dallas, Tex.)

Abbr.

Arteriosclerosis

ISSN

0276-5047

DOI

10.1161/01.atv.4.2.97

Published

1984-00-00

Pages

97-102

Language

English

Region

United States

NLM ID

8401388

Subset

Grants

NICHD NIH HHS · HD04807 · United States

NHLBI NIH HHS · HL15895 · United States

External Links

PubMed source DOI: 10.1161/01.atv.4.2.97

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Human apolipoprotein A-I--C-III gene complex is located on chromosome 11.

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