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PMID: 64120 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Chemical and histochemical studies of human alveolar collagen fibers.

The American journal of pathology ·Vol. 86 ·No. 1 ·1977-01-00 ·Pages 81-98

Huang W

Abstract

Light and electron microscopic studies have established that the normal human alveolar argyrophilic (reticulum) fiber is collagen fiber. The silver impregnation method is highly sensitive and specific for histologic demonstration of the elaborate collagen fiber network of alveolar septa. The argyrophilic alveolar collagen fiber does not stain with the periodic acid-Schiff (PAS) or periodic acid-thiocarbohydrazide-osmium tetroxide (PTO) reaction. The materials positive for the PAS and PTO reactions in alveolar septa are epithelial and endothelial basal laminas, which are nonargyrophilic. Chemically, lung collagen fibers are composed of Type I and Type III collagens, which differ in amino acid composition, chain composition, and carbohydrate content. The chemical heterogeneity of lung collagen may have important biologic implications in the maintenance of normal structure and in the repair of lung injury.

MeSH Terms
Adult Amino Acids/analysis Chemical Phenomena Chemistry Collagen/analysis,classification,metabolism Histocytochemistry Humans Microscopy, Electron Middle Aged Periodic Acid-Schiff Reaction Pulmonary Alveoli/metabolism Silver Staining and Labeling
Chemicals
Amino Acids Silver Collagen
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Huang W
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1977-01-00
Pages
81-98
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC2032049
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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