A maximum likelihood estimate of the sex ratio of mutation rates in haemophilia A.

Human genetics ·Vol. 64 ·No. 2 ·1983-00-00 ·Pages 156-9

Winter RM, Tuddenham EG, Goldman E, Matthews KB

Abstract

Carrier detection tests were carried out on 21 mothers of isolated cases of severe Haemophilia A, according to WHO recommendations. A maximum likelihood estimate of the male to female mutation ratio of 9.6 (95% confidence limits 2.2-41.5) was obtained.

MeSH Terms

Factor VIII/analysis Female Genetic Carrier Screening Hemophilia A/blood,genetics Humans Male Mutation Probability Sex Ratio

Chemicals

Factor VIII

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Winter R M

Tuddenham E G

Goldman E

Matthews K B

References (6)

6 references, click to expand

Estimation of proportion of new mutants among cases of Duchenne muscular dystrophy.
J Med Genet. 1978 Oct;15(5):339-45 PMID: 739522
Estimation of male to female ratio of mutation rates from carrier-detection tests in X-linked disorders.
Am J Hum Genet. 1980 Jul;32(4):582-8 PMID: 7395871
Equilibrium frequencies in X-linked recessive disease.
Am J Hum Genet. 1973 Jul;25(4):388-96 PMID: 4716658
Does unequal crossing over contribute to the mutation rate in Duchenne muscular dystrophy?
Am J Med Genet. 1982 Aug;12(4):437-41 PMID: 7124796
A probable sex difference in some mutation rates.
Am J Hum Genet. 1977 May;29(3):312-9 PMID: 868880
Genetic counseling in sex linkage.
Birth Defects Orig Artic Ser. 1979;15(5C):9-24 PMID: 393324

Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00327115

Published

1983-00-00

Pages

156-9

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00327115 View journal details

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A maximum likelihood estimate of the sex ratio of mutation rates in haemophilia A.

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