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PMID: 6406358 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Cell culture studies on neurofibromatosis (von Recklinghausen). II. Occurrence of glial cells in primary cultures of peripheral neurofibromas.

Human genetics ·Vol. 63 ·No. 3 ·1983-00-00 ·Pages 247-51

Krone W, Jirikowski G, Mühleck O, Kling H, Gall H

Abstract

The occurrence of glial cells in primary cultures established from peripheral neurofibromas of 18 patients with neurofibromatosis (von Recklinghausen) is described. The spindle-shaped cells can be distinguished from fibroblasts on the basis of morphological and ultrastructural criteria. As demonstrated by immunocytochemical analysis, the spindle cells express S-100 protein. Neither glial fibrillar acidic protein nor myelin basic protein can be detected in these cells. In many respects the spindle cells resemble immature Schwann cells in culture.

MeSH Terms
Cells, Cultured Humans Mitosis Nerve Tissue Proteins/analysis Neurofibromatosis 1/pathology Neuroglia/analysis,ultrastructure S100 Proteins/analysis
Chemicals
Nerve Tissue Proteins S100 Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Krone W
Jirikowski G
Mühleck O
Kling H
Gall H
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24 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00284658
Published
1983-00-00
Pages
247-51
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00284658 View journal details
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