Regulation of hexitol catabolism in Streptococcus mutans.
Regulation of hexitol catabolism was investigated in Streptococcus mutans, a cariogenic human dental plaque bacterium. Induction of hexitol catabolic enzymes and phosphoenolpyruvate:hexitol phosphotransferase and hexitol phosphate dehydrogenase activities was regulated by an inducer exclusion mechanism initiated by D-glucose and 2-deoxy-D-glucose. Kinetic analysis of the inhibitory effect of 2-deoxy-D-glucose on initial hexitol uptake illustrated that this was a noncompetitive type of inhibition. In mutant strains of S. mutans lacking phosphoenolpyruvate:glucose phosphotransferase activity, 2-deoxy-D-glucose was unable to inhibit hexitol uptake. These observations provide evidence for possible molecular mechanisms for the exclusion process.
16 references, click to expand
-
Sugar transport. I. Isolation of a phosphotransferase system from Escherichia coli.J Biol Chem. 1971 Mar 10;246(5):1393-406 PMID: 5545082
-
Mannitol and sorbitol catabolism in Streptococcus mutans.Arch Oral Biol. 1973 Jan;18(1):117-26 PMID: 4145128
-
Ethanol production and alcohol dehydrogenase activity in Streptococcus mutans.Arch Oral Biol. 1973 Jan;18(1):127-31 PMID: 4513107
-
Effect of sugar analogues on growth, sugar utilization, and acid production by Streptococcus mutans.J Dent Res. 1975 May-Jun;54(3):433-40 PMID: 1056348
-
Mannitol transport in Streptococcus mutans.J Bacteriol. 1975 Dec;124(3):1475-81 PMID: 1194241
-
Sugar transport. Properties of mutant bacteria defective in proteins of the phosphoenolpyruvate: sugar phosphotransferase system.J Biol Chem. 1976 Nov 10;251(21):6584-97 PMID: 789368
-
Sugar phosphate: sugar transphosphorylation and exchange group translocation catalyzed by the enzyme 11 complexes of the bacterial phosphoenolpyruvate: sugar phosphotransferase system.J Biol Chem. 1977 Dec 25;252(24):8899-907 PMID: 336623
-
Initial characterization of sucrose-6-phosphate hydrolase from Streptococcus mutans and its apparent identity with intracellular invertase.Biochem Biophys Res Commun. 1979 Jul 12;89(1):307-14 PMID: 224874
-
Control of phosphoenolpyruvate-dependent phosphotransferase-mediated sugar transport in Escherichia coli by energization of the cell membrane.Proc Natl Acad Sci U S A. 1979 Nov;76(11):5529-33 PMID: 392504
-
Carbohydrate transport in bacteria.Microbiol Rev. 1980 Sep;44(3):385-418 PMID: 6999324
-
Regulation of beta-galactoside phosphate accumulation in Streptococcus pyogenes by an expulsion mechanism.Proc Natl Acad Sci U S A. 1980 Sep;77(9):5497-501 PMID: 7001481
-
Generation of an electrochemical proton gradient in Streptococcus cremoris by lactate efflux.Proc Natl Acad Sci U S A. 1980 Sep;77(9):5502-6 PMID: 6254084
-
The staphylococcal phosphoenolpyruvate-dependent phosphotransferase system. Purification and characterisation of the galactoside-specific membrane-component enzyme II.Eur J Biochem. 1981 Jan;113(2):289-94 PMID: 7053084
-
Competition between two pathways for sugar uptake by the phosphoenolpyruvate-dependent sugar phosphotransferase system in Salmonella typhimurium.Eur J Biochem. 1981;114(1):51-8 PMID: 7011803
-
Regulation of methyl-beta-d-thiogalactopyranoside-6-phosphate accumulation in Streptococcus lactis by exclusion and expulsion mechanisms.J Bacteriol. 1981 Jun;146(3):885-94 PMID: 6787017
-
Protein measurement with the Folin phenol reagent.J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
