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PMID: 6392104 Published · ppublish English Comparative Study Journal Article

Serological diagnosis of erythema migrans disease and related disorders.

Infection ·Vol. 12 ·No. 5 ·1984-00-00 ·Pages 331-7

Wilske B, Schierz G, Preac-Mursic V, Weber K, Pfister HW, Einhäupl K

Abstract

An indirect immunofluorescence technique for the determination of antibodies against ixodid tick spirochetes is described. Differences in the reactivity between Ixodes ricinus spirochete and Ixodes dammini spirochete antigens were not observed. Cross-reacting antibodies against Treponema pallidum and Treponema phagedenis can be eliminated by quantitative absorption with T. phagedenis. Cross-reactions with leptospira were not observed by immunofluorescence. In the IgM test, false negative reactions caused by high-titered specific IgG antibodies or false positive reactions caused by rheumatoid factor occur. This can be avoided by testing the IgM fraction (19S-IgM-test) or using sera previously treated with anti-IgG serum. Significantly elevated antibody titers against ixodid tick spirochetes were observed in 45% of 44 cases with erythema migrans disease, in 72% of 29 cases of lymphocytic meningoradiculitis, in all of nine patients with acrodermatitis chronica atrophicans and in all of four investigated patients with lymphocytoma (lymphadenosis benigna cutis).

MeSH Terms
Acrodermatitis/diagnosis,immunology Adult Antibodies, Bacterial/analysis Cross Reactions Erythema/diagnosis,immunology Fluorescent Antibody Technique Humans Immunoglobulin G/analysis Immunoglobulin M/analysis Leptospira/immunology Lymphoma, Non-Hodgkin/diagnosis,immunology Meningitis/diagnosis,immunology Polyradiculopathy/diagnosis,immunology Skin Neoplasms/diagnosis,immunology Spirochaetales/immunology Spirochaetales Infections/diagnosis,immunology Treponema/immunology
Chemicals
Antibodies, Bacterial Immunoglobulin G Immunoglobulin M
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Wilske B
Schierz G
Preac-Mursic V
Weber K
Pfister H W
Einhäupl K
References (18)
18 references, click to expand
  1. Indirect immunofluorescence test for detection of IgM antibodies to cytomegalovirus.
    J Infect Dis. 1979 Oct;140(4):596-600 PMID: 229176
  2. Enzyme-linked immunosorbent assay and indirect immunofluorescence assay for Lyme disease.
    J Infect Dis. 1984 Mar;149(3):465-70 PMID: 6371156
  3. [Chronic erythema migrans and tick-transmitted meningopolyneuritis (Garin-Bujadoux-Bannwarth): Borrelia infections?].
    Dtsch Med Wochenschr. 1983 Apr 15;108(15):577-80 PMID: 6839977
  4. [Erythema chronicum migrans with arthritis (author's transl)].
    Dtsch Med Wochenschr. 1980 Dec 19;105(51):1779-81 PMID: 7439072
  5. [Spirochete etiology of erythema chronicum migrans disease].
    Dtsch Med Wochenschr. 1984 Jan 20;109(3):92-7 PMID: 6363033
  6. [Lyme arthritis (erythema migrans arthritis)].
    Schweiz Med Wochenschr. 1984 Feb 25;114(8):265-9 PMID: 6710111
  7. [Clinical aspects and etiology of acrodermatitis chronica atrophicans].
    Hautarzt. 1984 Nov;35(11):571-7 PMID: 6394553
  8. [Erythema migrans disease. A contribution to its clinical features and relation to Lyme disease].
    Dtsch Med Wochenschr. 1983 Aug 5;108(31-32):1182-90 PMID: 6872871
  9. [Meningopolyneuritis (Garin-Bujadoux, Bannwarth). Clinical aspects and laboratory findings].
    Nervenarzt. 1983 Dec;54(12):640-6 PMID: 6664392
  10. The spirochetal etiology of Lyme disease.
    N Engl J Med. 1983 Mar 31;308(13):733-40 PMID: 6828118
  11. The spirochetal etiology of lymphocytic meningoradiculitis of Bannwarth (Bannwarth's syndrome).
    J Neurol. 1984;231(3):141-4 PMID: 6481420
  12. [The 19S(IgM)-FTA-ABS test in the serodiagnosis of syphilis. Technique, sources of error and diagnostical information of results (author's transl)].
    Immun Infekt. 1982 Jan;10(1):23-34 PMID: 7040208
  13. European erythema migrans disease and related disorders.
    Yale J Biol Med. 1984 Jul-Aug;57(4):463-71 PMID: 6549090
  14. Antibodies to Lyme-disease spirochaete in European lymphocytic meningoradiculitis (Bannwarth's syndrome)
    Lancet. 1983 Aug 27;2(8348):519 PMID: 6136679
  15. Antibodies of patients with Lyme disease to components of the Ixodes dammini spirochete.
    J Clin Invest. 1983 Aug;72(2):504-15 PMID: 6348092
  16. Spirochetes isolated from the blood of two patients with Lyme disease.
    N Engl J Med. 1983 Mar 31;308(13):740-2 PMID: 6828119
  17. Lyme disease-a tick-borne spirochetosis?
    Science. 1982 Jun 18;216(4552):1317-9 PMID: 7043737
  18. [Serum antibodies against Ixodes ricinus Spirochaeta in acrodermatitis chronica atrophicans (Herxheimer)].
    Dtsch Med Wochenschr. 1984 Jan 6;109(1):6-10 PMID: 6363031
Article Info
Journal
Infection
Abbr.
Infection
ISSN
0300-8126
DOI
10.1007/BF01651147
Published
1984-00-00
Pages
331-7
Language
English
Region
Germany
NLM ID
0365307
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01651147 View journal details
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