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PMID: 6379510 Published · ppublish English Clinical Trial Comparative Study Journal Article Review

Chemotherapy of malignant gliomas.

Neurosurgical review ·Vol. 7 ·No. 1 ·1984-00-00 ·Pages 3-12

Ushio Y, Hayakawa T, Hasegawa H, Yamada K, Arita N

Abstract

Chemotherapy of malignant glioma has been discussed in relation to recent advances in experimental and clinical studies. It is now obvious that chemotherapy is of increasing importance in the multidisciplinary treatment of malignant gliomas. Survival time of patients was prolonged by intensive and prolonged chemotherapy and by second treatment upon tumour recurrence. Further progress of chemotherapy will be gained by the progressive accumulation of all experiences, however small, in all the varied routes of approach.

MeSH Terms
Animals Antineoplastic Agents/therapeutic use Blood-Brain Barrier Brain/pathology Cell Division/drug effects Clinical Trials as Topic Combined Modality Therapy Glioma/drug therapy,pathology,physiopathology,radiotherapy Humans Rats
Chemicals
Antineoplastic Agents
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ushio Y
Hayakawa T
Hasegawa H
Yamada K
Arita N
References (49)
49 references, click to expand
  1. Treatment of adult malignant gliomas.
    Recent Results Cancer Res. 1978;68:399-407 PMID: 752876
  2. Cisplatin therapy in recurrent childhood brain tumors.
    Cancer Treat Rep. 1982 Dec;66(12 ):2013-20 PMID: 6890409
  3. Intra-arterial BCNU therapy in the treatment of metastatic brain tumor from lung carcinoma: a preliminary report.
    Cancer. 1979 Dec;44(6):2000-7 PMID: 509386
  4. Proceedings: 4'-Demethyl-epipodophyllotoxin-beta-D-thenylidene-glucoside (PTG) in the treatment of malignant intracranial neoplasms.
    Cancer. 1974 Feb;33(2):460-7 PMID: 4812764
  5. Permeability characteristics of brain adjacent to tumors in rats.
    Arch Neurol. 1975 Dec;32(12):785-91 PMID: 1203030
  6. Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery.
    N Engl J Med. 1980 Dec 4;303(23):1323-9 PMID: 7001230
  7. High-dose methotrexate with citrovorum factor rescue for the treatment of central nervous system tumors in children.
    Cancer Treat Rep. 1977 Jul;61(4):681-90 PMID: 301781
  8. High-dose BCNU with autologous bone marrow rescue for recurrent glioblastoma multiforme.
    J Neurosurg. 1981 Apr;54(4):455-60 PMID: 6259300
  9. BCNU (NSC-409962) and procarbazine (NSC-77213) treatment for malignant brain tumors.
    Cancer Treat Rep. 1976 Mar;60(3):243-9 PMID: 177210
  10. Treatment of malignant gliomas and brain metastases in adults with a combination of adriamycin, VM 26, and CCNU. Results of a phase II trail.
    Cancer. 1976 Nov;38(5):1909-16 PMID: 1033028
  11. Combination chemotherapy with 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride and bleomycin in meningeal carcinomatosis in rats.
    Cancer Res. 1980 Apr;40(4):1341-3 PMID: 6153573
  12. A phase II study of methyl CCNU in the treatment of solid tumors and lymphomas: a Southwest Oncology Group study.
    Cancer. 1975 Apr;35(4):1148-53 PMID: 1116106
  13. Evaluation of CCNU, VM-26 plus CCNU, and procarbazine in supratentorial brain gliomas. Final evaluation of a randomized study. European Organization for Research on Treatment of Cancer (EORTC) Brain Tumor Group.
    J Neurosurg. 1981 Jul;55(1):27-31 PMID: 7017081
  14. Controlled study of CCNU and radiation therapy in malignant astrocytoma.
    J Neurosurg. 1976 Feb;44(2):186-90 PMID: 173814
  15. Adjuvant chemotherapy with VM 26 and CCNU after operation and radiotherapy of high-grade supratentorial astrocytomas.
    Surg Neurol. 1980 Jan;13(1):65-8 PMID: 6244679
  16. Combination chemotherapy with 1-(2-chloroethyl-3-cyclohexyl-1-nitrosourea) (CCNU), vincristine and methotrexate in primary and metastatic brain tumors--a preliminary report.
    Eur J Cancer. 1973 Sep;9(9):627-34 PMID: 4803230
  17. Treatment of malignant glioma. A controlled study of chemotherapy and irradiation.
    Arch Neurol. 1976 Jul;33(7):494-50 PMID: 180938
  18. Phase II study of procarbazine, CCNU, and vincristine combination chemotherapy in the treatment of malignant brain tumors.
    Cancer. 1975 May;35(5):1398-404 PMID: 1122488
  19. Effect of CCNU on survival rate of objective remission and duration of free interval in patients with malignant brain glioma--final evaluation. E.O.R.T.C. Brain Tumor Group.
    Eur J Cancer. 1978 Aug;14(8):851-6 PMID: 357162
  20. Chloroethyl-cyclohexyl-nitrosourea (CCNU) in the treatment of malignant brain tumors.
    J Neurosurg. 1973 Sep;39(3):306-14 PMID: 4354763
  21. Combination chemotherapy with VM 26 and CCNU in primary malignant brain tumors.
    Surg Neurol. 1979 Mar;11(3):237-42 PMID: 473022
  22. [Chemotherapy of malignant brain tumors: biology and pharmacokinetics (author's transl)].
    No Shinkei Geka. 1980 Nov;8(11):1007-16 PMID: 7005704
  23. Monitoring of methotrexate delivery in patients with malignant brain tumors after osmotic blood-brain barrier disruption.
    Ann Intern Med. 1981 Apr;94(4 pt 1):449-54 PMID: 6782926
  24. Combined chemotherapy with VM 26 and BCNU for recurrent malignant gliomas after operation and irradiation.
    Acta Neurochir (Wien). 1978;42(1-2):97-101 PMID: 696446
  25. Quantitative autoradiographic measurements of blood-brain barrier permeability in the rat glioma model.
    J Neurosurg. 1982 Sep;57(3):394-8 PMID: 7097336
  26. Chemotherapy: the agents in current use.
    Semin Oncol. 1975 Mar;2(1):63-7 PMID: 795035
  27. The application of brain capillary permeability coefficient measurements to pathological conditions and the selection of agents which cross the blood-brain barrier.
    J Pharmacokinet Biopharm. 1976 Dec;4(6):499-519 PMID: 827606
  28. Modified procarbazine, CCNU, and vincristine (PCV 3) combination chemotherapy in the treatment of malignant brain tumors.
    Cancer Treat Rep. 1980 Feb-Mar;64(2-3):237-44 PMID: 7407756
  29. Combined modality therapy of operated astrocytomas grade III and IV. Confirmation of the value of postoperative irradiation and lack of potentiation of bleomycin on survival time: a prospective multicenter trial of the Scandinavian Glioblastoma Study Group.
    Cancer. 1981 Feb 15;47(4):649-52 PMID: 6164465
  30. Reoperation for glioblastoma.
    J Neurosurg. 1981 Dec;55(6):917-21 PMID: 6271933
  31. BCNU-5-fluorouracil combination therapy for recurrent malignant brain tumors.
    Cancer Treat Rep. 1978 Dec;62(12):2071-6 PMID: 221113
  32. Chemotherapeutic implications of growth fraction and cell cycle time in glioblastomas.
    J Neurosurg. 1975 Aug;43(2):127-35 PMID: 1185245
  33. A phase III comparison of BCNU, hydroxyurea, and radiation therapy to BCNU and radiation therapy for treatment of primary malignant gliomas.
    J Neurosurg. 1979 Oct;51(4):526-32 PMID: 225456
  34. Pharmacodynamics and the blood-brain barrier.
    Natl Cancer Inst Monogr. 1977 Dec;46:19-27 PMID: 349396
  35. SENSITIVITY OF INTRACRANIAL GLIOMAS TO VINCRISTINE SULPHATE.
    Lancet. 1965 Feb 6;1(7380):296-8 PMID: 14247875
  36. Changes of the blood-brain barrier in experimental metastatic brain tumors.
    J Neurosurg. 1983 Aug;59(2):304-10 PMID: 6864299
  37. Changes in blood-brain transfer parameters induced by hyperosmolar intracarotid infusion and by metastatic tumor growth.
    Adv Exp Med Biol. 1980;131:307-19 PMID: 7435337
  38. The chemotherapy of brain tumors. Clinical experience with carmustine (BCNU) and vincristine.
    JAMA. 1972 Oct 30;222(5):549-52 PMID: 4343318
  39. Single-agent chemotherapy of brain tumors. A five-year review.
    Arch Neurol. 1976 Nov;33(11):739-44 PMID: 185991
  40. Enhancement of CNS penetration of methotrexate by hyperosmolar intracarotid mannitol or carcinomatous meningitis.
    Neurology. 1979 Sep;29(9 Pt 1):1280-6 PMID: 573408
  41. Survival response of malignant gliomas to radiotherapy with or without BCNU or methyl-CCNU chemotherapy at the University of Kentucky Medical Center.
    Cancer Treat Rep. 1981 Jan-Feb;65(1-2):45-51 PMID: 7013978
  42. Case report: acute leukemia after semustine (methyl-CCNU) therapy.
    Cancer Treat Rep. 1982 Jul;66(7):1593-4 PMID: 6953997
  43. Initial clinical trials with methyl-CCNU 1-(2-chlorethyl)-3-(4-methyl cyclohexyl)-1-nitrosourea (MeCCNU).
    Cancer. 1973 May;31(5):1164-9 PMID: 4705154
  44. Treatment of grade III and IV astrocytoma with dimethyl triazeno imidazole carboxamide (DTIC, NSC-45388) alone and in combination with CCNU (NSC-79037) or methyl CCNU (MeCCNU, NSC-95441).
    Cancer. 1975 Oct;36(4):1269-76 PMID: 169984
  45. Treatment of meningeal neoplasms.
    Cancer Treat Rep. 1977 Jul;61(4):733-43 PMID: 577896
  46. Testing of a hypothesis for osmotic opening of the blood-brain barrier.
    Am J Physiol. 1972 Aug;223(2):323-31 PMID: 5046750
  47. Effectiveness of the nitrosoureas as a function of their lipid solubility in the chemotherapy of experimental rat brain tumors.
    Cancer Chemother Rep. 1974 Nov-Dec;58(6):787-92 PMID: 4447922
  48. Response to vincristine of recurrent brain tumors in children.
    J Neurosurg. 1976 Aug;45(2):135-40 PMID: 939971
  49. Procarbazine hydrochloride in the treatment of brain tumors. Phase 2 study.
    J Neurosurg. 1974 Mar;40(3):365-71 PMID: 4360491
Article Info
Journal
Neurosurgical review
Abbr.
Neurosurg Rev
ISSN
0344-5607
Published
1984-00-00
Pages
3-12
Language
English
Region
Germany
NLM ID
7908181
Subset
IM
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