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PMID: 6377609 Published · ppublish English Case Reports Journal Article Research Support, Non-U.S. Gov't

Cyclosporin-associated central nervous system toxicity after allogeneic bone marrow transplantation.

Transplantation ·Vol. 38 ·No. 1 ·1984-07-00 ·Pages 34-7

Atkinson K, Biggs J, Darveniza P, Boland J, Concannon A, Dodds A

Abstract

Five of 64 recipients of HLA-identical sibling marrow allografts who were given cyclosporin (CSP) to minimize graft-versus-host disease posttransplant had a serious neurological illness thought to be due to CSP. Characteristic clinical features included a motor spinal cord syndrome, a cerebellar-like syndrome, and mental confusion. All five recovered when the CSP dose was reduced or the drug was stopped.

MeSH Terms

Acute Kidney Injury/chemically induced Adult Ataxia/chemically induced Bone Marrow Transplantation Central Nervous System Diseases/chemically induced Confusion/chemically induced Cyclosporins/therapeutic use,toxicity Female Graft vs Host Disease/prevention & control Humans Leukemia, Myeloid/therapy Male Memory Disorders/chemically induced Middle Aged Pyramidal Tracts/drug effects Tremor/chemically induced

Chemicals

Cyclosporins

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Atkinson K

Biggs J

Darveniza P

Boland J

Concannon A

Dodds A

Article Info

Journal

Transplantation

Abbr.

Transplantation

ISSN

0041-1337

DOI

10.1097/00007890-198407000-00009

Published

1984-07-00

Pages

34-7

Language

English

Region

United States

NLM ID

0132144

Subset

External Links

PubMed source DOI: 10.1097/00007890-198407000-00009 View journal details

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Cyclosporin-associated central nervous system toxicity after allogeneic bone marrow transplantation.

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