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PMID: 6372881 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A new theoretical index of biochemical reactivity combining steric and electrostatic factors. An application to yeast tRNAPhe.

Biophysical chemistry ·Vol. 19 ·No. 2 ·1984-03-00 ·Pages 171-81

Lavery R, Pullman A

Abstract

A new theoretical index of the chemical reactivity of sites within macromolecules is developed, which combines both steric and electrostatic factors. It is applied to the study of yeast tRNAPhe and the results obtained are compared with known experimental reactivities. A comparison indicates the superiority of the new index over the sole use of the surface accessibility.

MeSH Terms

Adenine Binding Sites Cations Chemical Phenomena Chemistry Chemistry, Physical Cytosine Electrochemistry Guanine Models, Biological Nucleic Acid Conformation Phosphates RNA, Fungal/metabolism RNA, Transfer, Amino Acyl/metabolism Saccharomyces cerevisiae Uracil

Chemicals

Cations Phosphates RNA, Fungal RNA, Transfer, Amino Acyl Uracil Guanine Cytosine Adenine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lavery R

Pullman A

Article Info

Journal

Biophysical chemistry

Abbr.

Biophys Chem

ISSN

0301-4622

DOI

10.1016/0301-4622(84)85017-6

Published

1984-03-00

Pages

171-81

Language

English

Region

Netherlands

NLM ID

0403171

Subset

External Links

PubMed source DOI: 10.1016/0301-4622(84)85017-6 View journal details

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A new theoretical index of biochemical reactivity combining steric and electrostatic factors. An application to yeast tRNAPhe.

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