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PMID: 6370690 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Laminin is induced in astrocytes of adult brain by injury.

The EMBO journal ·Vol. 3 ·No. 3 ·1984-03-00 ·Pages 683-6

Liesi P, Kaakkola S, Dahl D, Vaheri A

Abstract

Laminin is a high mol. wt. non-collagenous matrix glycoprotein, confined in adult tissues to basement membranes. In normal rat brain we found laminin mainly in vessel walls but, after injury, induced by stereotaxic injection of a neurotoxin, laminin immunoreactivity appeared also in reactive astrocytes, which are characteristically positive for the glial fibrillary acidic protein (GFAP). Laminin was first detected in GFAP-immunoreactive glial cells 24 h after injury. Four days later the majority of reactive astrocytes in the gray matter were positive for laminin and the laminin immunoreactivity, but not that of GFAP, gradually subsided within a month. Fibronectin, the other major matrix glycoprotein, was found only in capillary structures both in normal and lesioned brain tissue. The results indicate that mature astrocytes have the potential to produce laminin and suggest a role for this glycoprotein in brain regeneration.

MeSH Terms
Animals Astrocytes/metabolism Brain/physiology Capillaries/metabolism Fibronectins/metabolism Fluorescent Antibody Technique Gene Expression Regulation/drug effects Intermediate Filament Proteins/metabolism Kainic Acid/pharmacology Laminin/biosynthesis Male Nerve Regeneration Pyrrolidines/pharmacology Rats
Chemicals
Fibronectins Intermediate Filament Proteins Laminin Pyrrolidines Kainic Acid
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Liesi P
Kaakkola S
Dahl D
Vaheri A
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31 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1984-03-00
Pages
683-6
Language
English
Region
England
NLM ID
8208664
PMCID
PMC557407
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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