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PMID: 6369331 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Molecular model for elongation of the murein sacculus of Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 6 ·1984-03-00 ·Pages 1844-8

Burman LG, Park JT

Abstract

Labeling experiments are presented that suggest that new (radioactive) strands of murein are initially inserted adjacent to old strands. After 8 min, new strands start to be inserted adjacent to the previously inserted radioactive strands. Analysis of these data suggests that, for Escherichia coli to double the length of the sacculus in each generation, about 90 separate membrane-bound enzyme complexes travel unidirectionally around the circumference of the cell. They travel at a constant rate, six times each generation, synthesizing, inserting, and crosslinking two strands of murein at a time, thereby doubling the length of the sacculus.

MeSH Terms

Escherichia coli/metabolism Models, Biological Peptidoglycan/biosynthesis

Chemicals

Peptidoglycan

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Burman L G

Park J T

References (25)

25 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.81.6.1844

Published

1984-03-00

Pages

1844-8

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC345018

Subset

Grants

NIAID NIH HHS · AI-05090 · United States

External Links

PubMed source DOI: 10.1073/pnas.81.6.1844 PMC Full Text View journal details

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Molecular model for elongation of the murein sacculus of Escherichia coli.

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