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PMID: 6364484 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Major histocompatibility complex restriction and transplantation immunity. A possible solution to the allograft problem.

Transplantation ·Vol. 37 ·No. 1 ·1984-01-00 ·Pages 28-32

Silvers WK, Bartlett ST, Chen HD, Fleming HL, Naji A, Barker CF

Abstract

Studies of the survival of weakly histoincompatible skin grafts in which the Langerhans' cells (LC)5 have been replaced with major histocompatibility complex (MHC)-compatible or incompatible LC, as well as studies of the fate of cultured endocrine allografts in MHC-compatible and incompatible mice and rats, indicate that allografts are only recognized as foreign if they possess donor macrophages (or cells of this family), or if antigen presenting cells MHC-compatible with the graft can be provided by the host.

MeSH Terms

Animals Animals, Newborn/immunology Chimera Endocrine Glands/transplantation Female Graft Survival H-Y Antigen/immunology Heart Transplantation Histocompatibility Antigens/immunology Langerhans Cells/immunology Major Histocompatibility Complex Male Mice Organ Culture Techniques Rats Sex Factors Skin/immunology Skin Transplantation Transplantation Immunology

Chemicals

H-Y Antigen Histocompatibility Antigens

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Silvers W K

Bartlett S T

Chen H D

Fleming H L

Naji A

Barker C F

Article Info

Journal

Transplantation

Abbr.

Transplantation

ISSN

0041-1337

Published

1984-01-00

Pages

28-32

Language

English

Region

United States

NLM ID

0132144

Subset

Grants

NIADDK NIH HHS · AM-26007 · United States

NCI NIH HHS · CA-18640 · United States

External Links

PubMed source View journal details

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Major histocompatibility complex restriction and transplantation immunity. A possible solution to the allograft problem.

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