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PMID: 6363600 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Monocytosis in the BXSB model for systemic lupus erythematosus.

The Journal of experimental medicine ·Vol. 159 ·No. 2 ·1984-02-01 ·Pages 629-34

Wofsy D, Kerger CE, Seaman WE

Abstract

Autoimmunity in BXSB mice is associated with a progressive increase in the number of peripheral blood mononuclear cells (PBMC). This is due to a marked rise in circulating monocytes, identified by: (a) their appearance on light and electron microscopy; (b) their surface antigenic characteristics; (c) their expression of Fc receptors; and (d) their capacity for phagocytosis. Among murine models for systemic lupus erythematosus, only the BXSB strain is characterized by monocytosis, suggesting that cells of monocytic lineage may contribute significantly to the pathogenesis of autoimmune disease in BXSB mice.

MeSH Terms

Animals Antilymphocyte Serum/immunology Autoimmune Diseases/genetics,immunology Female Fluorescent Antibody Technique Leukocytosis/blood,genetics,immunology Lupus Erythematosus, Systemic/blood,genetics,immunology Male Mice Mice, Mutant Strains Monocytes/immunology,ultrastructure

Chemicals

Antilymphocyte Serum

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Wofsy D

Kerger C E

Seaman W E

References (14)

14 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.159.2.629

Published

1984-02-01

Pages

629-34

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2187231

Subset

External Links

PubMed source DOI: 10.1084/jem.159.2.629 PMC Full Text View journal details

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Monocytosis in the BXSB model for systemic lupus erythematosus.

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