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PMID: 6358858 Published · ppublish English Comparative Study Journal Article Review

The interaction of long-chain acyl CoA with membranes.

Molecular and cellular biochemistry ·Vol. 57 ·No. 1 ·1983-00-00 ·Pages 3-15

Brecher P

Abstract

Published data regarding the interaction of long-chain acyl CoA derivatives with the protein and phospholipid constituents of biological membranes is reviewed and discussed in relationship to the premise that such interactions may lead to membrane damage during pathological situations. The topics considered include: the detergent properties of long-chain CoA, the interaction with membrane-associated enzymes, biological membranes, or model membrane systems, and the binding to a soluble protein that may facilitate intracellular transport. The effects of long-chain acyl CoA on heart mitochondria and the relevance of such studies to myocardial ischemia also is emphasized.

MeSH Terms
Acyl Coenzyme A/metabolism,pharmacology Animals Coronary Disease/metabolism Detergents Enzymes/metabolism Fatty Acids/metabolism In Vitro Techniques Liver/metabolism Membranes/drug effects,metabolism Mitochondria, Heart/drug effects Myocardium/metabolism Polysaccharides/metabolism Rats
Chemicals
Acyl Coenzyme A Detergents Enzymes Fatty Acids Polysaccharides
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Brecher P
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87 references, click to expand
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Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
DOI
10.1007/BF00223520
Published
1983-00-00
Pages
3-15
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00223520 View journal details
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