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PMID: 6358721 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

beta-Lactamase inhibitors.

Medicinal research reviews ·Vol. 3 ·No. 4 ·1983-00-00 ·Pages 341-82

Cartwright SJ, Waley SG

Abstract

In summary, Table XVI shows the inhibition profiles of representative beta-lactamases from each major class of Richmond and Sykes. Either resistance (R) or sensitivity (S) is given as a general guide to the type of compounds likely to inhibit each class. Thus the (qualitative) statements regarding the effectiveness of clavulanic acid can be taken to represent those for the penam sulfones and similarly for MM4550 and the other olivanic acids, carpetimycins, PS series, and asparenomycins. This can also be said of cloxacillin and the other aromatic carboxamido penicillins. Compounds are also included which are specifically or particularly inhibitory to certain beta-lactamases.

MeSH Terms
Anti-Bacterial Agents/pharmacology Cephalosporins/pharmacology Gram-Negative Bacteria/drug effects Gram-Positive Bacteria/drug effects Humans Kinetics beta-Lactamase Inhibitors beta-Lactamases/classification,metabolism
Chemicals
Anti-Bacterial Agents Cephalosporins beta-Lactamase Inhibitors beta-Lactamases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cartwright S J
Waley S G
Article Info
Journal
Medicinal research reviews
Abbr.
Med Res Rev
ISSN
0198-6325
Published
1983-00-00
Pages
341-82
Language
English
Region
United States
NLM ID
8103150
Subset
IM
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