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PMID: 6350893 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Construction of artificial chromosomes in yeast.

Nature ·Vol. 305 ·No. 5931 ·1983-00-00 ·Pages 189-93

Murray AW, Szostak JW

Abstract

Fifty-five-kilobase long artificial chromosomes containing cloned genes, replicators, centromeres and telomeres have been constructed in yeast. These molecules have many of the properties of natural yeast chromosomes. Centromere function is impaired on short (less than 20 kilobases) artificial chromosomes.

MeSH Terms
Centromere/physiology Chromosomes/physiology Cloning, Molecular DNA Replication Genetic Engineering Meiosis Mitosis Plasmids Saccharomyces cerevisiae/genetics,ultrastructure
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Murray A W
Szostak J W
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/305189a0
Published
1983-00-00
Pages
189-93
Language
English
Region
England
NLM ID
0410462
Subset
IM
Grants
NCI NIH HHS · T32-CA09361 · United States
External Links
PubMed source DOI: 10.1038/305189a0 View journal details
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