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PMID: 6350527 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Target antigens of transmission-blocking immunity on gametes of plasmodium falciparum.

The Journal of experimental medicine ·Vol. 158 ·No. 3 ·1983-09-01 ·Pages 976-81

Rener J, Graves PM, Carter R, Williams JL, Burkot TR

Abstract

Three proteins of apparent molecular weights on reducing SDS-PAGE of 255, 59, and 53 kilodaltons have been identified as the targets on gametes of P. falciparum malaria of two monoclonal antibodies (MAbs) that act synergistically to block transmission of the parasites to mosquitoes.

MeSH Terms
Animals Anopheles/parasitology Antibodies, Monoclonal/immunology,physiology Antigen-Antibody Reactions Antigens/analysis,immunology,isolation & purification Binding, Competitive Female Fluorescent Antibody Technique Humans Insect Vectors/parasitology Malaria/immunology,parasitology,transmission Male Molecular Weight Plasmodium falciparum/growth & development,immunology,pathogenicity
Chemicals
Antibodies, Monoclonal Antigens
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Rener J
Graves P M
Carter R
Williams J L
Burkot T R
References (7)
7 references, click to expand
  1. Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion.
    Eur J Immunol. 1976 Jul;6(7):511-9 PMID: 825377
  2. Gamete development in malaria parasites: bicarbonate-dependent stimulation by pH in vitro.
    Parasitology. 1978 Feb;76(1):39-53 PMID: 23512
  3. Malaria immunization in Rhesus monkeys. A vaccine effective against both the sexual and asexual stages of Plasmodium knowlesi.
    J Exp Med. 1978 Nov 1;148(5):1311-23 PMID: 102724
  4. Immunisation against gametes and asexual erythrocytic stages of a rodent malaria parasite.
    Nature. 1979 Feb 1;277(5695):389-91 PMID: 551260
  5. Anti-gamete monoclonal antibodies synergistically block transmission of malaria by preventing fertilization in the mosquito.
    Proc Natl Acad Sci U S A. 1980 Nov;77(11):6797-9 PMID: 6935685
  6. Complete in vitro maturation of Plasmodium falciparum gametocytes.
    Nature. 1981 Nov 26;294(5839):364-6 PMID: 7031476
  7. Characterization of antigens on mosquito midgut stages of Plasmodium gallinaceum. I. Zygote surface antigens.
    Mol Biochem Parasitol. 1983 May;8(1):53-69 PMID: 6683783
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.158.3.976
Published
1983-09-01
Pages
976-81
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2187091
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.158.3.976 PMC Full Text View journal details
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