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PMID: 6347778 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Effect of insulin on human erythrocyte membrane fluidity in diabetes mellitus.

Diabetologia ·Vol. 24 ·No. 5 ·1983-05-00 ·Pages 311-3

Bryszewska M, Leyko W

Abstract

The effect of insulin in vitro on the fluidity of the human erythrocyte membrane in Type I (insulin-dependent) diabetic patients and healthy control subjects was investigated using a fluorescence technique. It was found that the addition of 10(-9) mol/l porcine insulin significantly increased fluorescent probe lateral mobility in the membrane lipid layer but did not appear to produce any conformational changes of membrane proteins.

MeSH Terms

Adult Diabetes Mellitus/blood Erythrocyte Membrane/drug effects Erythrocytes/drug effects Humans In Vitro Techniques Insulin/pharmacology Membrane Fluidity/drug effects Spectrometry, Fluorescence

Chemicals

Insulin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Bryszewska M

Leyko W

References (17)

17 references, click to expand

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Article Info

Journal

Diabetologia

Abbr.

Diabetologia

ISSN

0012-186X

DOI

10.1007/BF00251814

Published

1983-05-00

Pages

311-3

Language

English

Region

Germany

NLM ID

0006777

Subset

External Links

PubMed source DOI: 10.1007/BF00251814 View journal details

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