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PMID: 6343246 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Influence of preformed antibody on the pathogenesis of experimental Candida albicans endocarditis.

Infection and immunity ·Vol. 40 ·No. 3 ·1983-06-00 ·Pages 950-5

Scheld WM, Calderone RA, Brodeur JP, Sande MA

Abstract

The influence of preformed antibody on the induction of experimental Candida albicans endocarditis was investigated by both in vitro and in vivo techniques. Preincubation of C. albicans with immune serum (raised in rabbits by intravenous injection of Formalin-killed yeast cells) decreased adhesion to the constituents of nonbacterial thrombotic endocarditis, e.g., fibrin plus platelets, in vitro. Two different methods, with radiolabeled or viable yeast cells, were confirmatory and demonstrated decreased adhesion of immune serum-treated C. albicans cells to 0 to 7.8% of control values (P less than 0.001). These results correlated with protection from the development of C. albicans endocarditis in the immunized rabbits. The mean (+/- standard deviation) infectious dose for 50% of the animals was 10(5.29) +/- 10(0.07) in 48 control animals versus 10(7.11) +/- 10(0.22) in 37 immunized rabbits (P less than 0.001). These studies suggest that humoral antibody may protect against C. albicans endocarditis, perhaps through inhibition of adhesion, a crucial early step in the pathogenesis of endocarditis.

MeSH Terms
Adhesiveness Animals Antibodies, Fungal/physiology Blood Platelets/microbiology Candida albicans/immunology,physiology Candidiasis/immunology,microbiology Endocarditis/immunology,microbiology Fibrin Humans Immunization Rabbits
Chemicals
Antibodies, Fungal Fibrin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Scheld W M
Calderone R A
Brodeur J P
Sande M A
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.40.3.950-955.1983
Published
1983-06-00
Pages
950-5
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC348144
Subset
IM
Grants
NIAID NIH HHS · 1-K08-AI00517 · United States
NHLBI NIH HHS · 1-R23-HL21370 · United States
External Links
PubMed source DOI: 10.1128/iai.40.3.950-955.1983 PMC Full Text View journal details
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