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PMID: 6340107 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Multilocus genetic structure in natural populations of Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 80 ·No. 6 ·1983-03-00 ·Pages 1751-5

Whittam TS, Ochman H, Selander RK

Abstract

A survey of allozyme variation at 12 enzyme loci in 1,705 clones of the genetic species Escherichia coli (including four species of Shigella) from natural populations revealed 302 unique allele combinations (electrophoretic types). Single-locus diversity estimates fall within the range predicted by the neutral allele theory of molecular evolution, but the combination of alleles in electrophoretic types are highly nonrandom, as indicated by a test of association over all loci and by evidence of complex linkage disequilibria in several four-locus combinations. These linkage disequilibria reflect genetic differentiation of E. coli into three groups of strains. Because of restricted recombination, both the stochastic extinction of lines and selective differences between particular genetic combinations may have contributed to the evolution of subspecific structure in E. coli.

MeSH Terms
Electrophoresis Escherichia coli/enzymology,genetics Polymorphism, Genetic Shigella/genetics
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Whittam T S
Ochman H
Selander R K
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25 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.80.6.1751
Published
1983-03-00
Pages
1751-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC393682
Subset
IM
Grants
NIGMS NIH HHS · GM 22126 · United States
External Links
PubMed source DOI: 10.1073/pnas.80.6.1751 PMC Full Text View journal details
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