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PMID: 6339378 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Peroral immunization of rats with Escherichia coli heat-labile enterotoxin delivered by microspheres.

Infection and immunity ·Vol. 39 ·No. 2 ·1983-02-00 ·Pages 1000-3

Klipstein FA, Engert RF, Sherman WT

Abstract

The antigenicity of the Escherichia coli heat-labile enterotoxin was not protected against the adverse effect of gastric acidity when the toxin was given together with bicarbonate for peroral immunization to rats, but immunization with the heat-labile enterotoxin encapsulated in pH-dependent microspheres aroused the same strong degree of serum and mucosal antitoxin responses and of protection against challenge as was achieved by peroral immunization after ablation of gastric secretions by pretreatment with cimetidine.

MeSH Terms

Administration, Oral Animals Antitoxins/analysis Bacterial Toxins Bicarbonates/pharmacology Cimetidine/pharmacology Enterotoxins/immunology Escherichia coli Infections/prevention & control Escherichia coli Proteins Immunization/methods Immunization, Secondary Microspheres Rats Rats, Inbred Strains

Chemicals

Antitoxins Bacterial Toxins Bicarbonates Enterotoxins Escherichia coli Proteins heat stable toxin (E coli) Cimetidine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Klipstein F A

Engert R F

Sherman W T

References (12)

12 references, click to expand

Isolation and characterization of homogeneous heat-labile enterotoxins with high specific activity from Escherichia coli cultures.
Infect Immun. 1979 Jun;24(3):760-9 PMID: 89088
Protective effect of active immunization with purified Escherichia coli heat-labile enterotoxin in rats.
Infect Immun. 1979 Mar;23(3):592-9 PMID: 378831
Induction of a mucosal antitoxin response and its role in immunity to experimental canine cholera.
Infect Immun. 1978 Jul;21(1):185-93 PMID: 711314
Antigenicity of purified glutaraldehyde-treated cholera toxoid administered orally.
Infect Immun. 1978 Jul;21(1):158-62 PMID: 101456
Immunity to experimental cholera. III. Enhanced duration of protection after sequential parenteral-oral administration of toxoid to dogs.
J Infect Dis. 1977 Jun;135(6):888-96 PMID: 864285
Arousal of mucosal secretory immunoglobulin A antitoxin in rats immunized with Escherichia coli heat-labile enterotoxin.
Infect Immun. 1982 Sep;37(3):1086-92 PMID: 7129629
Influence of route of administration on immediate and extended protection in rats immunized with Escherichia coli heart-labile enterotoxin.
Infect Immun. 1980 Jan;27(1):81-6 PMID: 6987180
Protective effect of immunization of rats with holotoxin or B subunit of Escherichia coli heat-labile enterotoxin.
Infect Immun. 1981 Jan;31(1):144-50 PMID: 7011990
Comparative study of varying regimens to improve steatorrhoea and creatorrhoea in cystic fibrosis: Effectiveness of an enteric-coated preparation with and without antacids and cimetidine.
Lancet. 1981 Nov 14;2(8255):1071-4 PMID: 6118524
Intestinal antibody responses after immunisation with cholera B subunit.
Lancet. 1982 Feb 6;1(8267):305-8 PMID: 6120313
Development of a vaccine of cross-linked heat-stable and heat-labile enterotoxins that protects against Escherichia coli producing either enterotoxin.
Infect Immun. 1982 Aug;37(2):550-7 PMID: 6749682
An enteric-coated pancreatic enzyme preparation that works.
Dig Dis Sci. 1979 Dec;24(12):906-9 PMID: 510089

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.39.2.1000-1003.1983

Published

1983-02-00

Pages

1000-3

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC348049

Subset

External Links

PubMed source DOI: 10.1128/iai.39.2.1000-1003.1983 PMC Full Text View journal details

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Peroral immunization of rats with Escherichia coli heat-labile enterotoxin delivered by microspheres.

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