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PMID: 6338024 Published · ppublish English Comparative Study Journal Article Review

Interleukin 2: biology and biochemistry.

Journal of clinical immunology ·Vol. 3 ·No. 1 ·1983-01-00 ·Pages 1-13

Gillis S

Abstract

Since its discovery as a T-cell growth factor, interleukin 2 (IL-2) has attracted considerable scientific attention, not only as a useful reagent for the maintenance of large numbers of effector T lymphocytes but as a potentially potent immunoregulatory molecule, which could be of therapeutic usefulness in a number of clinical conditions. Outlined in this communication is a summary of the more salient biochemical features of murine and human IL-2, as well as the results of initial molecular biology experimentation aimed at the eventual production of IL-2 by recombinant DNA methodologies. These studies, together with those detailing the in vivo effectiveness of IL-2 therapy in a number of murine model situations, provide a current glimpse of future IL-2 aims and directions.

MeSH Terms
Animals Cell Division Cytotoxicity, Immunologic Humans Interleukin-2/biosynthesis,immunology,isolation & purification Killer Cells, Natural/immunology Male Mice Protein Biosynthesis RNA, Messenger/genetics T-Lymphocytes/immunology
Chemicals
Interleukin-2 RNA, Messenger
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Gillis S
References (35)
35 references, click to expand
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Article Info
Journal
Journal of clinical immunology
Abbr.
J Clin Immunol
ISSN
0271-9142
DOI
10.1007/BF00919133
Published
1983-01-00
Pages
1-13
Language
English
Region
Netherlands
NLM ID
8102137
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00919133 View journal details
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