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题目:: Expression of cell surface determinant(s) on murine myeloma stem cells and hematopoietic stem cells.
作者:: Daley(M J),Williams(T),Warner(N L)
状态:: 发布时间1985-03-08 , 更新时间 2007-11-14
期刊:: Eur J Immunol
摘要:: Murine B cell lymphomas and myelomas were examined for the expression of a determinant previously found exclusively on normal pluripotent stem cells colony-forming unit-spleen (CFU-s). This determinant(s), which is defined by a rabbit antimouse brain antiserum (R alpha MB), is present on the tumor stem cell population of some but not all B cell neoplasms examined. The determinant is not detected on tumor cells of the macrophage or T cell lineage. Absorption of the activity in R alpha MB with myeloma cells, concomitantly removed reactivity with the normal stem cell, CFU-s, and the myeloma stem cell, plasmacytoma CFU-s. Sorting analysis further showed that the antigen was diminished within a positive tumor population as cells acquired the capacity to secrete immunoglobulin. These studies suggest that this normal stem cell-associated antigen may also be an early differentiation antigen for the B cell lineage, and is expressed on some stem cells of B cell tumors.
语言:: eng
DOI:: 10.1002/eji.1830141206

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