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PMID: 6330900 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Cellular transformation by human papillomavirus DNA in vitro.

Science (New York, N.Y.) ·Vol. 225 ·No. 4662 ·1984-08-10 ·Pages 634-6

Watts SL, Phelps WC, Ostrow RS, Zachow KR, Faras AJ

Abstract

Molecularly cloned DNA's of human papillomaviruses HPV-5 and HPV-l induced morphological transformation of mouse C127 cells in culture. Single-cell clones of cells transformed by papillomavirus contained multiple persistent episomal copies of the transfected DNA species and were analyzed for growth characteristics indicating malignant potential.

MeSH Terms

Animals Carcinoma/microbiology Cell Transformation, Neoplastic/metabolism Cell Transformation, Viral Clone Cells DNA, Viral/metabolism Humans Mice Mice, Nude Papillomaviridae/genetics,metabolism Transfection Tumor Virus Infections/genetics

Chemicals

DNA, Viral

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Watts S L

Phelps W C

Ostrow R S

Zachow K R

Faras A J

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6330900

Published

1984-08-10

Pages

634-6

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NCI NIH HHS · CA 06653 · United States

NCI NIH HHS · CA 25462 · United States

External Links

PubMed source DOI: 10.1126/science.6330900 View journal details

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Cellular transformation by human papillomavirus DNA in vitro.

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