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PMID: 6329453 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Identification of an amiloride sensitive Na+/H+ exchange system in brain synaptosomes.

Brain research ·Vol. 301 ·No. 2 ·1984-06-03 ·Pages 371-4

Sauvaigo S, Vigne P, Frelin C, Lazdunski M

Abstract

This paper reports the presence of a Na+-uptake component in rat brain synaptosomes that is coupled to H+-efflux as monitored from the acidification of the extrasynaptosomal space. This exchange mechanism is inhibited by amiloride and two of its more potent derivatives: dimethylamiloride and ethylisopropylamiloride.

MeSH Terms
Acid-Base Equilibrium/drug effects Amiloride/pharmacology Animals Brain/drug effects Culture Techniques Ion Channels/drug effects Kinetics Pyrazines/pharmacology Rats Sodium/metabolism Synaptosomes/drug effects
Chemicals
Ion Channels Pyrazines Amiloride Sodium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sauvaigo S
Vigne P
Frelin C
Lazdunski M
Article Info
Journal
Brain research
Abbr.
Brain Res
ISSN
0006-8993
DOI
10.1016/0006-8993(84)91106-5
Published
1984-06-03
Pages
371-4
Language
English
Region
Netherlands
NLM ID
0045503
Subset
IM
External Links
PubMed source DOI: 10.1016/0006-8993(84)91106-5 View journal details
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