Home LiteratureArticle Details
PMID: 6328042 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A murine model for oral infection with a primate rotavirus (simian SA11).

Journal of virology ·Vol. 51 ·No. 1 ·1984-07-00 ·Pages 233-6

Offit PA, Clark HF, Kornstein MJ, Plotkin SA

Abstract

Simian rotavirus SA11 was shown to replicate in the gastrointestinal tracts of infant mice after oral inoculation. Clinical symptoms, histopathological changes in the small intestinal mucosa, and the type-specific humoral immune response were all characteristic of rotavirus-induced gastroenteritis. The availability of this small animal model for the study of a primate rotavirus infection should expedite analysis of the immune response necessary for protection against challenge.

MeSH Terms
Animals Antibodies, Viral/analysis Antibody Formation Diarrhea/microbiology Disease Models, Animal Ileum/pathology Mice Rotavirus/immunology Rotavirus Infections/physiopathology
Chemicals
Antibodies, Viral
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Offit P A
Clark H F
Kornstein M J
Plotkin S A
References (24)
24 references, click to expand
  1. Importance of a new virus in acute sporadic enteritis in children.
    Lancet. 1975 Feb 1;1(7901):242-6 PMID: 46387
  2. Pathogenesis of rotavirus infection in mice.
    Infect Immun. 1982 Nov;38(2):755-63 PMID: 6292110
  3. Oral administration of human rotavirus to volunteers: induction of illness and correlates of resistance.
    J Infect Dis. 1983 Jan;147(1):95-106 PMID: 6296243
  4. Studies on the etiology and transmission of epidemic diarrhea of infant mice.
    J Exp Med. 1957 Nov 1;106(5):743-55 PMID: 13475628
  5. Response of mice to rotaviruses of bovine or primate origin assessed by radioimmunoassay, radioimmunoprecipitation, and plaque reduction neutralization.
    Infect Immun. 1983 Oct;42(1):293-300 PMID: 6311747
  6. Morphological and antigenic relationships between viruses (rotaviruses) from acute gastroenteritis of children, calves, piglets, mice, and foals.
    Infect Immun. 1976 Sep;14(3):804-10 PMID: 965097
  7. Human reovirus-like agent as the major pathogen associated with "winter" gastroenteritis in hospitalized infants and young children.
    N Engl J Med. 1976 Apr 29;294(18):965-72 PMID: 176586
  8. Studies on cross protection induced in calves by rotaviruses of calves, children and foals.
    Vet Rec. 1978 Jul 8;103(2):32-4 PMID: 210557
  9. The clinical response of gnotobiotic calves, pigs and lambs to inoculation with human, calf, pig and foal rotavirus isolates.
    Aust J Exp Biol Med Sci. 1980 Jun;58(3):309-18 PMID: 6257218
  10. Rotavirus infection in lambs: pathogenesis and pathology.
    Arch Virol. 1977;55(4):263-74 PMID: 202226
  11. Plaque assay of neonatal calf diarrhea virus and the neutralizing antibody in human sera.
    J Clin Microbiol. 1977 Jan;5(1):1-4 PMID: 188863
  12. Susceptibility of mice to rotavirus infection: effects of age and administration of corticosteroids.
    Infect Immun. 1981 Aug;33(2):565-74 PMID: 6268547
  13. The cultivation of human rotavirus, strain 'Wa', to high titer in cell culture and characterization of the viral structural polypeptides.
    J Virol Methods. 1983 Jul;7(1):29-40 PMID: 6311856
  14. Distribution and titres of rotavirus antibodies in different age groups.
    J Hyg (Lond). 1977 Dec;79(3):365-72 PMID: 200676
  15. Human rotavirus in lambs: infection and passive protection.
    Infect Immun. 1977 Apr;16(1):268-70 PMID: 194837
  16. Antigenic relationships among some animal rotaviruses: virus neutralization in vitro and cross-protection in piglets.
    J Clin Microbiol. 1982 Sep;16(3):495-503 PMID: 6290530
  17. Simian virus SA11 and the related O agent.
    Arch Gesamte Virusforsch. 1967;22(1):235-45 PMID: 4972061
  18. The isolation of reovirus-like agents (rota-viruses) from acute gastroenteritis of piglets.
    J Med Microbiol. 1976 May;9(2):203-9 PMID: 180294
  19. The isolation of a reovirus-like agent associated with diarrhoea in colostrum-deprived calves in Great Britain.
    Res Vet Sci. 1974 Jan;16(1):102-5 PMID: 4362255
  20. Approaches to immunization of infants and young children against gastroenteritis due to rotaviruses.
    Rev Infect Dis. 1980 May-Jun;2(3):459-69 PMID: 6251528
  21. Isolation and characterization of a canine rotavirus.
    Arch Virol. 1982;72(1-2):113-25 PMID: 6179502
  22. Isolation of lapine rotavirus in cell cultures. Brief report.
    Arch Virol. 1982;71(3):267-71 PMID: 6285861
  23. Diarrhea in gnotobiotic calves caused by the reovirus-like agent of human infantile gastroenteritis.
    Infect Immun. 1976 Aug;14(2):471-4 PMID: 184047
  24. Serological relationships between rotaviruses from different species as studied by complement fixation and neutralization.
    Arch Virol. 1977;53(4):287-94 PMID: 68765
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.51.1.233-236.1984
Published
1984-07-00
Pages
233-6
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC254422
Subset
IM
Grants
NIAID NIH HHS · F-32 AI-06733 · United States
External Links
PubMed source DOI: 10.1128/JVI.51.1.233-236.1984 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2