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PMID: 6324700 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Clostridial toxins in neonatal necrotising enterocolitis.

Archives of disease in childhood ·Vol. 59 ·No. 3 ·1984-03-00 ·Pages 270-2

Thomas DF, Fernie DS, Bayston R, Spitz L

Abstract

Clostridium difficile cytopathic toxin was found in the faeces or gut content of five of 39 neonates with necrotising enterocolitis (NEC). Toxin concentrations were uniformly low and did not differ from those found in healthy neonates. C difficile is unlikely to be involved in the pathogenesis of NEC. Stools from 33 babies with NEC were also tested for C perfringens alpha toxin, with negative results.

MeSH Terms

Bacterial Proteins Bacterial Toxins/analysis Calcium-Binding Proteins Clostridium Infections Clostridium perfringens Cytotoxins/analysis Enterocolitis, Pseudomembranous/etiology Feces/analysis Humans Infant, Newborn Type C Phospholipases

Chemicals

Bacterial Proteins Bacterial Toxins Calcium-Binding Proteins Cytotoxins toxB protein, Clostridium difficile Type C Phospholipases alpha toxin, Clostridium perfringens

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Thomas D F

Fernie D S

Bayston R

Spitz L

References (6)

6 references, click to expand

Neonatal necrotizing enterocolitis: absence of enteric bacterial toxins.
N Engl J Med. 1978 Aug 24;299(8):424 PMID: 672944
Bacterial toxin and neonatal necrotizing enterocolitis.
J Pediatr. 1980 Jan;96(1):114-5 PMID: 7350290
Clostridia colonization and clostridial toxin in neonatal necrotizing enterocolitis.
J Pediatr. 1981 Feb;98(2):308-11 PMID: 7463233
Association between Clostridium difficile and enterocolitis in Hirschsprung's disease.
Lancet. 1982 Jan 9;1(8263):78-9 PMID: 6119496
Clostridium difficile toxin in asymptomatic neonates.
J Pediatr. 1982 Mar;100(3):431-4 PMID: 7062179
The prevalence of Clostridium difficile and toxin in a nursery population: a comparison between patients with necrotizing enterocolitis and an asymptomatic group.
J Pediatr. 1982 Mar;100(3):435-9 PMID: 7062180

Article Info

Journal

Archives of disease in childhood

Abbr.

Arch Dis Child

ISSN

1468-2044

DOI

10.1136/adc.59.3.270

Published

1984-03-00

Pages

270-2

Language

English

Region

England

NLM ID

0372434

PMCID

PMC1628537

Subset

External Links

PubMed source DOI: 10.1136/adc.59.3.270 PMC Full Text View journal details

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