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PMID: 6323742 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Characteristics and functions of Sendai virus-specific T-cell clones.

Journal of virology ·Vol. 50 ·No. 2 ·1984-05-00 ·Pages 425-31

Ertl HC, Finberg RW

Abstract

Several murine Sendai virus-specific T-cell clones were characterized in vitro and in vivo. All T-cell clones were phenotypically Thy-1.2+, and most clones were Lyt-1+,2-; one T-cell clone was Lyt-1-,2-. Some of the clones proliferated in response to antigen presented on I region-compatible stimulator cells. Proliferation could be inhibited by monoclonal antibodies directed against class II antigens. Clones which proliferated in response to antigen secreted lymphokines which could be identified as Interleukin 2 and Interleukin 3. All of the clones tested in vivo induced a delayed-type hypersensitivity response in syngeneic mice challenged with antigens. Depending on the experimental conditions chosen, Interleukin 2-producing clones as well as non-Interleukin 2-producing clones mediated help for stimulation of cytolytic T lymphocytes.

MeSH Terms
Animals Cells, Cultured Clone Cells Cytotoxicity, Immunologic DNA Replication Female Hypersensitivity, Delayed Lymph Nodes/microbiology Lymphokines/biosynthesis Mice Mice, Inbred Strains Parainfluenza Virus 1, Human/immunology,radiation effects Species Specificity Spleen/microbiology T-Lymphocytes/immunology Ultraviolet Rays
Chemicals
Lymphokines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ertl H C
Finberg R W
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27 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.50.2.425-431.1984
Published
1984-05-00
Pages
425-31
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC255636
Subset
IM
Grants
NIAID NIH HHS · AI-20382 · United States
External Links
PubMed source DOI: 10.1128/JVI.50.2.425-431.1984 PMC Full Text View journal details
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