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PMID: 6320641 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Estimation of the marker gene frequency and linkage disequilibrium from conditional marker data.

American journal of human genetics ·Vol. 36 ·No. 1 ·1984-01-00 ·Pages 177-86

Chakravarti A, Li CC, Buetow KH

Abstract

A method is proposed to calculate the maximum likelihood estimate of gene frequency and linkage disequilibrium from disease-codominant marker conditional data. The method is illustrated using data on sickle-cell anemia and Duchenne muscular dystrophy and linked polymorphic restriction endonuclease cleavage sites.

MeSH Terms
Anemia, Sickle Cell/genetics Chromosome Mapping DNA Restriction Enzymes/genetics Gene Frequency Genes, Dominant Genetic Linkage Genetic Markers Genotype Humans Models, Genetic Muscular Dystrophies/genetics Polymorphism, Genetic
Chemicals
Genetic Markers DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Chakravarti A
Li C C
Buetow K H
References (11)
11 references, click to expand
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1984-01-00
Pages
177-86
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1684398
Subset
IM
Grants
NIADDK NIH HHS · 2R01AM13983-14 · United States
External Links
PubMed source PMC Full Text View journal details
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