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PMID: 6320117 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Transcription in vivo of an Alu family member upstream from the human epsilon-globin gene.

Nucleic acids research ·Vol. 12 ·No. 2 ·1984-01-25 ·Pages 1193-200

Allan M, Paul J

Abstract

The more distal Alu repeat flanking the epsilon-globin gene is transcribed in K562 cells to generate transcripts 350-400 nucleotides in length. Initiation occurs at the start of the repeat, upstream of a putative PolIII control signal. These transcripts originate from the strand which does not code epsilon-globin and are oriented in the opposite direction from the gene. They are non-polyadenylated, nucleus-confined and are only detectable in association with expression of the epsilon-globin gene.

MeSH Terms
Cell Line Codon Endonucleases Genes Globins/genetics Humans Leukemia, Myeloid, Acute Lymphocytes/metabolism Nucleic Acid Hybridization Single-Strand Specific DNA and RNA Endonucleases Transcription, Genetic
Chemicals
Codon Globins Endonucleases Single-Strand Specific DNA and RNA Endonucleases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Allan M
Paul J
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22 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/12.2.1193
Published
1984-01-25
Pages
1193-200
Language
English
Region
England
NLM ID
0411011
PMCID
PMC318565
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/12.2.1193 PMC Full Text View journal details
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