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PMID: 6320017 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Two configurations of a channel-forming membrane protein.

Nature ·Vol. 307 ·No. 5952 ·1984-00-00 ·Pages 609-13

Unwin PN, Ennis PD

Abstract

The protein oligomer forming the gap junction channel has been analysed in two Ca2+-sensitive states by electron microscopy of membranes in frozen aqueous solutions. Switching between states occurs by a small cooperative rearrangement involving tilting of the subunits, which may be responsible for the effect of Ca2+ on channel permeability in vivo.

MeSH Terms
Animals Calcium/physiology Connexins Intercellular Junctions/physiology,ultrastructure Liver/ultrastructure Membrane Proteins Rats X-Ray Diffraction
Chemicals
Connexins Membrane Proteins Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Unwin P N
Ennis P D
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/307609a0
Published
1984-00-00
Pages
609-13
Language
English
Region
England
NLM ID
0410462
Subset
IM
External Links
PubMed source DOI: 10.1038/307609a0 View journal details
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