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PMID: 6312099 Published · ppublish English Comparative Study Journal Article

Host range mutants of human rhinovirus in which nonstructural proteins are altered.

Journal of virology ·Vol. 48 ·No. 2 ·1983-11-00 ·Pages 410-8

Yin FH, Lomax NB

Abstract

Human rhinovirus type 2 did not replicate in nonpermissive mouse cells; the restriction was not in adsorption but in the early events of virus replication. Mutants which had been adapted to grow in mouse cells had the following characteristics: (i) no change in the structural protein, (ii) a larger nonstructural protein and its precursor protein, and (iii) an altered viral RNA synthesis. The altered nonstructural proteins correlated with a change in host range of the virus and may be involved in viral RNA synthesis.

MeSH Terms
Animals Capsid Genes, Viral HeLa Cells Hot Temperature Humans L Cells Mice Molecular Weight Mutation Protein Precursors RNA, Viral/biosynthesis Rhinovirus/growth & development Viral Proteins/biosynthesis,physiology
Chemicals
Protein Precursors RNA, Viral Viral Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Yin F H
Lomax N B
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.48.2.410-418.1983
Published
1983-11-00
Pages
410-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC255366
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.48.2.410-418.1983 PMC Full Text View journal details
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