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Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors.
J Clin Invest. 1981 Nov;68(5):1197-206
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Type III hyperlipoproteinemia associated with apolipoprotein E deficiency.
Science. 1981 Dec 11;214(4526):1239-41
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Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man.
Nature. 1977 Oct 13;269(5629):604-7
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Characterization of chylomicron remnant binding to rat liver membranes.
J Lipid Res. 1982 Jan;23(1):42-52
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Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight.
J Biol Chem. 1982 Mar 10;257(5):2664-73
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Effects of cholestyramine on low density lipoprotein binding sites on liver membranes from rabbits with endogenous hypercholesterolemia induced by a wheat starch-casein diet.
J Biol Chem. 1982 Apr 10;257(7):3623-7
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Human apolipoprotein E. The complete amino acid sequence.
J Biol Chem. 1982 Apr 25;257(8):4171-8
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Receptor-dependent and receptor-independent degradation of low density lipoprotein in normal rabbits and in receptor-deficient mutant rabbits.
J Biol Chem. 1982 Jul 25;257(14):7994-8000
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Tissue sites of degradation of native and reductively methylated [14C]sucrose-labeled low density lipoprotein in rats. Contribution of receptor-dependent and receptor-independent pathways.
J Biol Chem. 1982 Jul 25;257(14):8001-8
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Impaired receptor-mediated catabolism of low density lipoprotein in the WHHL rabbit, an animal model of familial hypercholesterolemia.
Proc Natl Acad Sci U S A. 1982 May;79(10):3305-9
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Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.
Proc Natl Acad Sci U S A. 1982 Jun;79(11):3623-7
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Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects.
Proc Natl Acad Sci U S A. 1982 Aug;79(15):4696-700
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The effect of partial ileal bypass on receptor-mediated uptake and catabolism of low density lipoprotein in the rhesus monkey.
Res Exp Med (Berl). 1982;180(3):263-70
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Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits.
Proc Natl Acad Sci U S A. 1982 Sep;79(18):5693-7
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Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia.
Cell. 1982 Oct;30(3):715-24
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Receptor-mediated uptake of hypertriglyceridemic very low density lipoproteins by normal human fibroblasts.
J Lipid Res. 1982 Sep;23(7):984-93
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Glycosylation of LDL decreases its ability to interact with high-affinity receptors of human fibroblasts in vitro and decreases its clearance from rabbit plasma in vivo.
Biochim Biophys Acta. 1982 Nov 12;713(2):199-207
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The LDL receptor locus in familial hypercholesterolemia: multiple mutations disrupt transport and processing of a membrane receptor.
Cell. 1983 Mar;32(3):941-51
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Identical structural and receptor binding defects in apolipoprotein E2 in hypo-, normo-, and hypercholesterolemic dysbetalipoproteinemia.
J Clin Invest. 1983 Apr;71(4):1023-31
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Characterization of the sinusoidal transport process responsible for uptake of chylomicrons by the liver.
J Biol Chem. 1978 Mar 25;253(6):1859-67
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Receptor-mediated low density lipoprotein catabolism in man.
J Lipid Res. 1979 Nov;20(8):999-1006
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Rapid hepatic clearance of the canine lipoproteins containing only the E apoprotein by a high affinity receptor. Identity with the chylomicron remnant transport process.
J Biol Chem. 1980 Mar 10;255(5):1804-7
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Inhibition of receptor-mediated clearance of lysine and arginine-modified lipoproteins from the plasma of rats and monkeys.
Proc Natl Acad Sci U S A. 1980 Jan;77(1):225-9
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Cholestyramine promotes receptor-mediated low-density-lipoprotein catabolism.
N Engl J Med. 1980 May 29;302(22):1219-22
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Determinants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat.
J Biol Chem. 1980 Jun 10;255(11):5475-80
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Receptor binding of cholesterol-induced high-density lipoproteins containing predominantly apoprotein E to cultured fibroblasts with mutations at the low-density lipoprotein receptor locus.
Biochemistry. 1980 Sep 2;19(18):4359-65
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The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that membrane mediates the uptake of rat lipoproteins containing apoproteins B and E.
J Biol Chem. 1980 Nov 10;255(21):10464-71
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Isoprotein specificity in the hepatic uptake of apolipoprotein E and the pathogenesis of familial dysbetalipoproteinemia.
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4349-53
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Partial purification and characterization of the low density lipoprotein receptor from bovine adrenal cortex.
J Biol Chem. 1980 Dec 10;255(23):11442-7
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Receptor-dependent uptake of human chylomicron remnants by cultured skin fibroblasts.
J Biol Chem. 1981 Jan 10;256(1):425-33
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Type III hyperlipoproteinemia: defective metabolism of an abnormal apolipoprotein E.
Science. 1981 Feb 6;211(4482):584-6
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Association of isoapolipoprotein-E3 deficiency with heterozygous familial hypercholesterolaemia: implications for lipoprotein physiology.
Lancet. 1981 Feb 7;1(8215):298-301
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Genetic transmission of isoapolipoprotein E phenotypes in a large kindred: relationship to dysbetalipoproteinemia and hyperlipidemia.
Metabolism. 1981 Jan;30(1):79-88
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Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification.
Biochemistry. 1981 Feb 17;20(4):1033-41
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Immunologic cross-reactivity of the low density lipoprotein receptor from bovine adrenal cortex, human fibroblasts, canine liver and adrenal gland, and rat liver.
J Biol Chem. 1981 Apr 25;256(8):4071-8
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Regulation of plasma cholesterol by lipoprotein receptors.
Science. 1981 May 8;212(4495):628-35
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Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.
Proc Natl Acad Sci U S A. 1981 Feb;78(2):1194-8
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Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits.
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1396-400
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Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors.
J Biol Chem. 1981 Jun 10;256(11):5646-55
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Defects of receptor-mediated low density lipoprotein catabolism in homozygous familial hypercholesterolemia and hypothyroidism in vivo.
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2591-5
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Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows.
J Clin Invest. 1981 Oct;68(4):1075-85
PMID: 6270194
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Regulation of hepatic lipoprotein receptors in the dog. Rapid regulation of apolipoprotein B,E receptors, but not of apolipoprotein E receptors, by intestinal lipoproteins and bile acids.
J Clin Invest. 1983 Apr;71(4):816-31
PMID: 6300188
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Receptor-mediated catabolism of low density lipoprotein in man. Quantitation using glucosylated low density lipoprotein.
J Clin Invest. 1983 Apr;71(4):950-9
PMID: 6300194
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Comparison of glucosylated low density lipoprotein with methylated or cyclohexanedione-treated low density lipoprotein in the measurement of receptor-independent low density lipoprotein catabolism.
J Clin Invest. 1983 Apr;71(4):960-4
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Apolipoprotein B: structural and metabolic heterogeneity.
Annu Rev Physiol. 1983;45:637-50
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Lipoprotein receptors and cholesterol homeostasis.
Biochim Biophys Acta. 1983 May 24;737(2):197-222
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Rates of receptor-dependent and -independent low density lipoprotein uptake in the hamster.
Proc Natl Acad Sci U S A. 1983 Jun;80(11):3499-503
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