Botulinum A toxin and tetanus toxin do not affect presynaptic membrane currents in mammalian motor nerve endings.

Brain research ·Vol. 270 ·No. 2 ·1983-07-04 ·Pages 373-5

Dreyer F, Mallart A, Brigant JL

Abstract

The hypothesis according to which BoTx and TeTx block neuromuscular transmission by impairing Ca2+ influx was tested by recording presynaptic membrane currents at motor endplates of the mouse by means of external electrodes. The use of K-channel blockers allowed us to observe inward Ca current which was unaffected by bath application of BoTx or TeTx at doses which block neuromuscular transmission.

MeSH Terms

Animals Botulinum Toxins/pharmacology Calcium/metabolism Cell Membrane Permeability/drug effects Ion Channels/drug effects Mice Motor Neurons/drug effects Neuromuscular Junction/drug effects Potassium/metabolism Sodium/metabolism Synaptic Transmission/drug effects Tetanus Toxin/pharmacology

Chemicals

Ion Channels Tetanus Toxin Sodium Botulinum Toxins Potassium Calcium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Dreyer F

Mallart A

Brigant J L

Article Info

Journal

Brain research

Abbr.

Brain Res

ISSN

0006-8993

DOI

10.1016/0006-8993(83)90617-0

Published

1983-07-04

Pages

373-5

Language

English

Region

Netherlands

NLM ID

0045503

Subset

External Links

PubMed source DOI: 10.1016/0006-8993(83)90617-0 View journal details

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Botulinum A toxin and tetanus toxin do not affect presynaptic membrane currents in mammalian motor nerve endings.

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