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PMID: 6307873 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Detection of antigenically distinct rotaviruses from infants.

Infection and immunity ·Vol. 41 ·No. 2 ·1983-08-00 ·Pages 523-6

Dimitrov DH, Estes MK, Rangelova SM, Shindarov LM, Melnick JL, Graham DY

Abstract

Antigenically distinct rotaviruses, i.e., viruses morphologically identical to conventional rotaviruses by electron microscopy, yet lacking the common group antigen(s) detected by an enzyme-linked immunosorbent assay, were found in 2 of 51 fecal samples from Bulgarian infants with rotavirus gastroenteritis. These antigenically distinct viruses contained 11 segments of double-stranded RNA, but they demonstrated a unique RNA migration profile after electrophoresis of the genome RNA in polyacrylamide gels. This report confirms the presence of a new group of rotaviruses in humans. The significance of these viruses is currently unknown, and specific diagnostic tests must be developed for epidemiological studies to determine their role as human and veterinary pathogens and to evaluate their impact on proposed vaccine development programs.

MeSH Terms

Antigens, Viral/analysis Bulgaria Child, Preschool Diarrhea, Infantile/immunology Electrophoresis, Polyacrylamide Gel Humans Infant RNA, Viral/analysis Rotavirus/immunology Rotavirus Infections/immunology

Chemicals

Antigens, Viral RNA, Viral

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Dimitrov D H

Estes M K

Rangelova S M

Shindarov L M

Melnick J L

Graham D Y

References (14)

14 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.41.2.523-526.1983

Published

1983-08-00

Pages

523-6

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC264672

Subset

Grants

NIADDK NIH HHS · AM 30144 · United States

External Links

PubMed source DOI: 10.1128/iai.41.2.523-526.1983 PMC Full Text View journal details

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Detection of antigenically distinct rotaviruses from infants.

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