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PMID: 6304480 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Active immunization with feline leukemia virus envelope glycoprotein suppresses growth of virus-induced feline sarcoma.

Medical microbiology and immunology ·Vol. 171 ·No. 4 ·1983-00-00 ·Pages 233-41

Hunsmann G, Pedersen NC, Theilen GH, Bayer H

Abstract

The efficiency was examined of immunization with feline leukemia virus glycoprotein complexes (gp85 rosettes) to protect cats against tumors induced by feline sarcoma virus (FeSV). The glycoprotein was isolated from feline leukemia virus (FeLV). Young cats were vaccinated with the purified viral glycoprotein and challenged with FeSV (FeLV). FeLV gp85 antibody levels were measured by enzyme-linked immunosorbent assay and tumor volumes were determined. In immunized animals tumor development was reduced. Gp85 antibody levels before challenge were correlated inversely with tumor size (r2 = 0.79). This method appears to be suitable for fast and efficient testing of future FeLV vaccines.

MeSH Terms
Animals Antibodies, Viral/analysis,immunology Antibody Formation Cats Enzyme-Linked Immunosorbent Assay Glycoproteins/immunology Immunization Leukemia Virus, Feline/immunology Sarcoma, Experimental/immunology Viral Proteins/immunology
Chemicals
Antibodies, Viral Glycoproteins Viral Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Hunsmann G
Pedersen N C
Theilen G H
Bayer H
References (17)
17 references, click to expand
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Article Info
Journal
Medical microbiology and immunology
Abbr.
Med Microbiol Immunol
ISSN
0300-8584
DOI
10.1007/BF02123497
Published
1983-00-00
Pages
233-41
Language
English
Region
Germany
NLM ID
0314524
Subset
IM
Grants
NCI NIH HHS · R0I CA 1689-06 · United States
External Links
PubMed source DOI: 10.1007/BF02123497 View journal details
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